1 Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA. jl346@email.med.yale.edu
A protein complex deposited upstream of exon-exon junctions after pre-mRNA splicing may serve a dual role in mRNA quality control by directing mRNA nuclear export and, possibly, serving as a downstream 'mark' for nonsense-mediated decay.