Abstract
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Chromones / chemical synthesis
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Chromones / chemistry*
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Chromones / pharmacology*
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Cyclin-Dependent Kinases / antagonists & inhibitors
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Drug Screening Assays, Antitumor
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology*
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Flavonoids / chemistry*
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Flavonoids / metabolism
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Flavonoids / pharmacology*
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Piperidines / chemistry*
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Piperidines / metabolism
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Piperidines / pharmacology*
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Pyridines / chemical synthesis
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Pyridines / chemistry*
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Pyridines / pharmacology*
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Structure-Activity Relationship*
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Tumor Cells, Cultured
Substances
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2-(2-chlorophenyl)-5,7-dihydroxy-8-(2,3,6-trihydro-1-methylpyridin-4-yl)benzopyran-4-one
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Antineoplastic Agents
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Chromones
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Enzyme Inhibitors
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Flavonoids
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Piperidines
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Pyridines
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alvocidib
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Cyclin-Dependent Kinases