Abstract
Legionella pneumophila is the causative agent of a potentially fatal form of pneumonia named Legionnaires' disease. L. pneumophila survives and replicates inside macrophages by preventing phagosome-lysosome fusion. A large number of L. pneumophila genes, called dot or icm, have been identified that are required for intracellular growth. It has recently been shown that the dot/icm genes code for a putative large membrane complex that forms a type IV secretion system used to alter the endocytic pathway.
MeSH terms
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Amoeba / microbiology
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Animals
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Bacterial Proteins / genetics
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Caenorhabditis elegans Proteins*
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Carrier Proteins / genetics
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Culture Media
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Cytotoxins / biosynthesis
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Escherichia coli Proteins*
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Genes, Bacterial / genetics
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Humans
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Legionella pneumophila / genetics
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Legionella pneumophila / growth & development
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Legionella pneumophila / pathogenicity
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Legionella pneumophila / physiology*
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Macrophages / microbiology
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Microtubule-Associated Proteins / genetics
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Periplasmic Proteins*
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Repressor Proteins / genetics
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Sodium Chloride
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U937 Cells
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Virulence
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Virulence Factors*
Substances
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Bacterial Proteins
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Caenorhabditis elegans Proteins
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Carrier Proteins
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Culture Media
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Cytotoxins
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Escherichia coli Proteins
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Microtubule-Associated Proteins
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PTL-1 protein, C elegans
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Periplasmic Proteins
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Repressor Proteins
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Virulence Factors
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trbA protein, E coli
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Sodium Chloride