Protein Family Models for Protein (Select 2248341449) - Protein Family Models

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Links from Protein

Items: 6

Select item 4110191.

This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor. [1]. 8831789. Crystal structure of the pyridoxal-5'-phosphate dependent. cystathionine beta-lyase from Escherichia coli at 1.83 A.. Clausen T, Huber R, Laber B, Pohlenz HD, Messerschmidt A;. J Mol Biol 1996;262:202-224.. [2]. 9843488. Crystal structure of Escherichia coli cystathionine. gamma-synthase at 1.5 A resolution.. Clausen T, Huber R, Prade L, Wahl MC, Messerschmidt A;. EMBO J 1998;17:6827-6838. (from Pfam)

GO Terms:

Biological Process:: transsulfuration (GO:0019346)

Molecular Function:: pyridoxal phosphate binding (GO:0030170)

Date:: 2024-08-14

Family Accession:: NF013237.5
Method:: HMM

Select item 3883592.

new record, indexing in progress

Family Accession:

Select item 3473803.

new record, indexing in progress

Family Accession:

Select item 2031334.

cystathionine beta-lyase

cystathionine beta-lyase primarily catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis; also exhibits cysteine desulfhydrase activity, producing sulfide from cysteine; under certain growth conditions, exhibits significant alanine racemase coactivity

Date:: 2020-11-20

Family Accession:: 10012871
Method:: Sparcle

Select item 1621695.

cystathionine beta-lyase

Catalyzes the formation of L-homocysteine from cystathionine

GO Terms:

Biological Process:: transsulfuration (GO:0019346)

Molecular Function:: cysteine-S-conjugate beta-lyase activity (GO:0047804)

Date:: 2024-05-02

Family Accession:: NF005456.0
Method:: HMM

Select item 1414326.

cystathionine beta-lyase

This HMM represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.