RecName: Full=[Pyruvate dehydrogenase [acetyl-transferring]]-phosphata - Protein

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PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia. [Leukemia. 2023]
PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia.
Alshamleh I, Kurrle N, Makowka P, Bhayadia R, Kumar R, Süsser S, Seibert M, Ludig D, Wolf S, Koschade SE, et al. Leukemia. 2023 Dec; 37(12):2367-2382. Epub 2023 Nov 7.
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling. [Cell Death Dis. 2021]
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca(2+)](m)-PDP1-PDH-histone acetylation retrograde signaling.
Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F. Cell Death Dis. 2021 Sep 6; 12(9):837. Epub 2021 Sep 6.
A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency. [JIMD Rep. 2019]
A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency.
Bedoyan JK, Hecht L, Zhang S, Tarrant S, Bergin A, Demirbas D, Yang E, Shin HK, Grahame GJ, DeBrosse SD, et al. JIMD Rep. 2019 Jul; 48(1):26-35. Epub 2019 Jun 17.

RefSeq genomic sequence
See the genomic reference sequence for the PDP1 gene (NG_012233.1).
RefSeq protein isoforms
See 16 reference sequence protein isoforms for the PDP1 gene.

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Q9P0J1 [Domain Mapping of Disease Mut...]
Q9P0J1
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
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Protein