RecName: Full=Volume-regulated anion channel subunit LRRC8E; AltName: - Protein

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LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. [Proc Natl Acad Sci U S A. 2020]
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.
Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, et al. Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46):29155-29165. Epub 2020 Nov 2.
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. [Mol Cell. 2020]
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.
Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L. Mol Cell. 2020 Nov 19; 80(4):578-591.e5. Epub 2020 Nov 9.
LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins. [FEBS Lett. 2004]
LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.
Kubota K, Kim JY, Sawada A, Tokimasa S, Fujisaki H, Matsuda-Hashii Y, Ozono K, Hara J. FEBS Lett. 2004 Apr 23; 564(1-2):147-52.

RefSeq genomic sequence
See the genomic reference sequence for the LRRC8E gene (NG_050684.1).
RefSeq protein isoforms
See 7 reference sequence protein isoforms for the LRRC8E gene.

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Q6NSJ5 [Domain Mapping of Disease Mut...]
Q6NSJ5
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

Metastatic Renal Cell Carcinoma
Metastatic Renal Cell Carcinoma

MedGen
Focal Segmental Glomerulosclerosis Collapsing Variant
Focal Segmental Glomerulosclerosis Collapsing Variant

MedGen
Medullary Cystic Kidney Disease Type II
Medullary Cystic Kidney Disease Type II

MedGen
Kidney hypertrophy
Kidney hypertrophy

MedGen
Nephropathy due to Tacrolimus
Nephropathy due to Tacrolimus

MedGen

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Protein