RecName: Full=DNA replication ATP-dependent helicase/nuclease DNA2; Sh - Protein

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Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma. [Nat Commun. 2024]
Targeting DNA2 overcomes metabolic reprogramming in multiple myeloma.
Thongon N, Ma F, Baran N, Lockyer P, Liu J, Jackson C, Rose A, Furudate K, Wildeman B, Marchesini M, et al. Nat Commun. 2024 Feb 8; 15(1):1203. Epub 2024 Feb 8.
Biallelic variants in DNA2 cause poikiloderma with congenital cataracts and severe growth failure reminiscent of Rothmund-Thomson syndrome. [J Med Genet. 2023]
Biallelic variants in DNA2 cause poikiloderma with congenital cataracts and severe growth failure reminiscent of Rothmund-Thomson syndrome.
Di Lazzaro Filho R, Yamamoto GL, Silva TJ, Rocha LA, Linnenkamp BDW, Castro MAA, Bartholdi D, Schaller A, Leeb T, Kelmann S, et al. J Med Genet. 2023 Nov; 60(11):1127-1132. Epub 2023 Apr 13.
Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma. [J Zhejiang Univ Sci B. 2023]
Estrogen upregulates DNA2 expression through the PI3K-AKT pathway in endometrial carcinoma.
Wang X, Xu X, Zhang T, Jin Y, Xu S, Chen L, Lai Y, Zhang L, Pan R, Yu Y. J Zhejiang Univ Sci B. 2023 Mar 15; 24(3):262-268.

RefSeq genomic sequence
See the genomic reference sequence for the DNA2 gene (NG_034247.1).
RefSeq protein isoforms
See 7 reference sequence protein isoforms for the DNA2 gene.

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Transcript/Protein Information [PANTHER Classification System]
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PANTHER Classification System
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Protein