methyl-CpG-binding domain protein 4 isoform 1 [Homo sapiens]

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Familial uveal melanoma and other tumors in 25 families with monoallelic germline MBD4 variants. [J Natl Cancer Inst. 2024]
Familial uveal melanoma and other tumors in 25 families with monoallelic germline MBD4 variants.
Villy MC, Le Ven A, Le Mentec M, Masliah-Planchon J, Houy A, Bièche I, Vacher S, Vincent-Salomon A, Dubois d'Enghien C, Schwartz M, et al. J Natl Cancer Inst. 2024 Apr 5; 116(4):580-587.
MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density. [J Exp Clin Cancer Res. 2023]
MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density.
Papin C, Ibrahim A, Sabir JSM, Le Gras S, Stoll I, Albiheyri RS, Zari AT, Bahieldin A, Bellacosa A, Bronner C, et al. J Exp Clin Cancer Res. 2023 Nov 14; 42(1):301. Epub 2023 Nov 14.
MBD4 deficiency is predictive of response to immune checkpoint inhibitors in metastatic uveal melanoma patients. [Eur J Cancer. 2022]
MBD4 deficiency is predictive of response to immune checkpoint inhibitors in metastatic uveal melanoma patients.
Saint-Ghislain M, Derrien AC, Geoffrois L, Gastaud L, Lesimple T, Negrier S, Penel N, Kurtz JE, Le Corre Y, Dutriaux C, et al. Eur J Cancer. 2022 Sep; 173:105-112. Epub 2022 Jul 19.

RefSeq genomic sequence
See the genomic reference sequence for the MBD4 gene (NG_033106.1).
RefSeq mRNA
See reference mRNA sequence for the MBD4 gene (NM_003925.3).
RefSeq protein isoforms
See 9 reference sequence protein isoforms for the MBD4 gene.

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NP_003916 [Domain Mapping of Disease Mut...]
NP_003916
Domain Mapping of Disease Mutations
Ensembl [Ensembl]
Ensembl
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
Find Quality Antibodies [GeneTex Inc]
Find Quality Antibodies
GeneTex Inc

thymocyte nuclear protein 1 [Rattus norvegicus]
thymocyte nuclear protein 1 [Rattus norvegicus]
gi|56090477|ref|NP_001007662.1|

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