Neurexin 2 p.G849D variant, implicated in Parkinson's disease, increases reactive oxygen species, and reduces cell viability and mitochondrial membrane potential in SH-SY5Y cells.
Cuttler K, de Swardt D, Engelbrecht L, Kriel J, Cloete R, Bardien S. J Neural Transm (Vienna). 2022 Dec; 129(12):1435-1446. Epub 2022 Oct 15.