volume-regulated anion channel subunit LRRC8E isoform 2 [Homo sapiens]

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Show in Genome Data Viewer
Opens the Genome Data Viewer, NCBI's genome browser, at the genomic location at which this sequence is annotated. View this sequence in the context of other features annotated at the same location and browse to other genome regions.

LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses. [Proc Natl Acad Sci U S A. 2020]
LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.
Li P, Hu M, Wang C, Feng X, Zhao Z, Yang Y, Sahoo N, Gu M, Yang Y, Xiao S, et al. Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46):29155-29165. Epub 2020 Nov 2.
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP. [Mol Cell. 2020]
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.
Lahey LJ, Mardjuki RE, Wen X, Hess GT, Ritchie C, Carozza JA, Böhnert V, Maduke M, Bassik MC, Li L. Mol Cell. 2020 Nov 19; 80(4):578-591.e5. Epub 2020 Nov 9.
LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins. [FEBS Lett. 2004]
LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.
Kubota K, Kim JY, Sawada A, Tokimasa S, Fujisaki H, Matsuda-Hashii Y, Ozono K, Hara J. FEBS Lett. 2004 Apr 23; 564(1-2):147-52.

RefSeq mRNA
See reference mRNA sequence for the LRRC8E gene (NM_001268285.3).
RefSeq protein isoforms
See 7 reference sequence protein isoforms for the LRRC8E gene.

BioProject
Proteins related to BioProjects
Nucleotide
Nucleotide sequence from coding region
PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Encoding mRNA
Link from protein to encoding mRNA
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Genome
Genome record encoding protein sequence
OMIM
OMIM records associated with protein sequence
Protein (UniProtKB)
Protein gi (refseq) to protein gi (UniProtKB)
PubMed (RefSeq)
Link to RefSeq PubMed articles
PubMed (Weighted)
Links to pubmed
SNP
Related SNPs

Ensembl [Ensembl]
Ensembl
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome