Cryo-EM structures reveal two allosteric inhibition modes of PI3Kα(H1047R) involving a re-shaping of the activation loop.
Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, et al. Structure. 2024 Jul 11; 32(7):907-917.e7. Epub 2024 Apr 5.