RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; AltName: - Protein

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer. [Chem Biol Interact. 2024]
Therapeutic targeting of thioredoxin reductase 1 causes ferroptosis while potentiating anti-PD-1 efficacy in head and neck cancer.
Hsieh MS, Ling HH, Setiawan SA, Hardianti MS, Fong IH, Yeh CT, Chen JH. Chem Biol Interact. 2024 May 25; 395:111004. Epub 2024 Apr 16.
Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells. [Biomed Pharmacother. 2024]
Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells.
Shen X, Xia Y, Lu H, Zheng P, Wang J, Chen Y, Xu C, Qiu C, Zhang Y, Xiao Z, et al. Biomed Pharmacother. 2024 May; 174:116507. Epub 2024 Apr 1.
Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif. [Redox Biol. 2024]
Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif.
Shi W, Sun S, Liu H, Meng Y, Ren K, Wang G, Liu M, Wu J, Zhang Y, Huang H, et al. Redox Biol. 2024 Apr; 70:103050. Epub 2024 Jan 18.

RefSeq genomic sequence
See the genomic reference sequence for the TXNRD1 gene (NG_029392.1).
RefSeq protein isoforms
See 7 reference sequence protein isoforms for the TXNRD1 gene.

PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioAssay by Target (Summary)
BioAssay by Target (Summary)
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Identical Structures
3D structures for identical protein sequences
OMIM
OMIM records associated with protein sequence
Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq)
PubMed (Weighted)
Links to pubmed
Related Structures (List)
List of related structures

Q16881 [Domain Mapping of Disease Mut...]
Q16881
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; AltName: Full=Gene...
RecName: Full=Thioredoxin reductase 1, cytoplasmic; Short=TR; AltName: Full=Gene associated with retinoic and interferon-induced mortality 12 protein; Short=GRIM-12; Short=Gene associated with retinoic and IFN-induced mortality 12 protein; AltName: Full=KM-102-derived reductase-like factor; AltName: Full=Peroxidase TXNRD1; AltName: Full=Thioredoxin reductase TR1
gi|172046253|sp|Q16881.3|TRXR1_HUMA

Protein
648[uid] AND (alive[prop]) (1)
Gene
BMI1 BMI1 proto-oncogene, polycomb ring finger [Homo sapiens]
BMI1 BMI1 proto-oncogene, polycomb ring finger [Homo sapiens]
Gene ID:648

Gene

Your browsing activity is empty.

Activity recording is turned off.

Protein