RecName: Full=Deoxyribonuclease-2-alpha; AltName: Full=Acid DNase; Alt - Protein

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Janus kinase inhibition for autoinflammation in patients with DNASE2 deficiency. [J Allergy Clin Immunol. 2020]
Janus kinase inhibition for autoinflammation in patients with DNASE2 deficiency.
Hong Y, Capitani M, Murphy C, Pandey S, Cavounidis A, Takeshita H, Nanthapisal S, Yasuda T, Bader-Meunier B, McCreary D, et al. J Allergy Clin Immunol. 2020 Feb; 145(2):701-705.e8. Epub 2019 Nov 24.
Type I interferon-mediated autoinflammation due to DNase II deficiency. [Nat Commun. 2017]
Type I interferon-mediated autoinflammation due to DNase II deficiency.
Rodero MP, Tesser A, Bartok E, Rice GI, Della Mina E, Depp M, Beitz B, Bondet V, Cagnard N, Duffy D, et al. Nat Commun. 2017 Dec 19; 8(1):2176. Epub 2017 Dec 19.
Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands. [J Immunol. 2015]
Cutting Edge: DNase II deficiency prevents activation of autoreactive B cells by double-stranded DNA endogenous ligands.
Pawaria S, Moody K, Busto P, Nündel K, Choi CH, Ghayur T, Marshak-Rothstein A. J Immunol. 2015 Feb 15; 194(4):1403-7. Epub 2015 Jan 19.

RefSeq protein
See the reference protein sequence for deoxyribonuclease-2-alpha precursor (NP_001366.1).

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O00115 [Domain Mapping of Disease Mut...]
O00115
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
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ExactAntigen/Labome

RecName: Full=Deoxyribonuclease-2-alpha; AltName: Full=Acid DNase; AltName: Full...
RecName: Full=Deoxyribonuclease-2-alpha; AltName: Full=Acid DNase; AltName: Full=Deoxyribonuclease II alpha; Short=DNase II alpha; AltName: Full=Lysosomal DNase II; AltName: Full=R31240_2; Flags: Precursor
gi|3182984|sp|O00115.2|DNS2A_HUMAN

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