RecName: Full=Cyclin-dependent kinase 12; AltName: Full=Cdc2-related k - Protein

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Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease. [JCO Precis Oncol. 2024]
Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease.
Bhogal T, Giannoudis A, Sokol E, Ali S, Palmieri C. JCO Precis Oncol. 2024 Jun; 8:e2300639.
Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. [Nucleic Acids Res. 2023]
Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release.
Wang Z, Himanen SV, Haikala HM, Friedel CC, Vihervaara A, Barborič M. Nucleic Acids Res. 2023 Nov 10; 51(20):10970-10991.
Prognostic and clinicopathological value of CDK12 mutation in prostate cancer: a meta-analysis. [Expert Rev Anticancer Ther. 2023]
Prognostic and clinicopathological value of CDK12 mutation in prostate cancer: a meta-analysis.
Zhang W, Zhou L, Di J. Expert Rev Anticancer Ther. 2023 Feb; 23(2):207-216. Epub 2023 Feb 3.

RefSeq protein isoforms
See 98 reference sequence protein isoforms for the CDK12 gene.

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Q9NYV4 [Domain Mapping of Disease Mut...]
Q9NYV4
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

RecName: Full=Cyclin-dependent kinase 12; AltName: Full=Cdc2-related kinase, arg...
RecName: Full=Cyclin-dependent kinase 12; AltName: Full=Cdc2-related kinase, arginine/serine-rich; Short=CrkRS; AltName: Full=Cell division cycle 2-related protein kinase 7; Short=CDC2-related protein kinase 7; AltName: Full=Cell division protein kinase 12; Short=hCDK12
gi|308153421|sp|Q9NYV4.2|CDK12_HUMA

Protein
crk [Polyodon spathula]
crk [Polyodon spathula]
Gene ID:121308658

Gene

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Protein