RecName: Full=Cyclin-dependent kinase 7; AltName: Full=39 kDa protein - Protein

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CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release. [Mol Cell. 2024]
CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release.
Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, et al. Mol Cell. 2024 Jun 20; 84(12):2287-2303.e10. Epub 2024 May 30.
CDK7 in breast cancer: mechanisms of action and therapeutic potential. [Cell Commun Signal. 2024]
CDK7 in breast cancer: mechanisms of action and therapeutic potential.
Gong Y, Li H. Cell Commun Signal. 2024 Apr 11; 22(1):226. Epub 2024 Apr 11.
Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction. [J Biol Chem. 2023]
Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction.
Piemonte KM, Webb BM, Bobbitt JR, Majmudar PR, Cuellar-Vite L, Bryson BL, Latina NC, Seachrist DD, Keri RA. J Biol Chem. 2023 Jul; 299(7):104834. Epub 2023 May 17.

RefSeq protein isoforms
See 14 reference sequence protein isoforms for the CDK7 gene.

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P50613 [Domain Mapping of Disease Mut...]
P50613
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=Cyclin-dependent kinase 7; AltName: Full=39 kDa protein kinase; Sh...
RecName: Full=Cyclin-dependent kinase 7; AltName: Full=39 kDa protein kinase; Short=p39 Mo15; AltName: Full=CDK-activating kinase 1; AltName: Full=Cell division protein kinase 7; AltName: Full=Serine/threonine-protein kinase 1; AltName: Full=TFIIH basal transcription factor complex kinase subunit
gi|1705722|sp|P50613.1|CDK7_HUMAN

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