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Select item 39205841.

Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth

Ramon C. Sun, Nicholas C. Denko

Cell Metab. Author manuscript; available in PMC 2015 Feb 4.

Published in final edited form as: Cell Metab. 2014 Feb 4; 19(2): 285–292. doi: 10.1016/j.cmet.2013.11.022

PMCID:: PMC3920584

Abstract Article PDF–2.2M

Select item 485742.

Cloning and nucleotide sequence of the cDNA encoding human 2-oxoglutarate dehydrogenase (lipoamide).

K Koike, Y Urata, S Goto

Proc Natl Acad Sci U S A. 1992 Mar 1; 89(5): 1963–1967. doi: 10.1073/pnas.89.5.1963

PMCID:: PMC48574

Summary Page Browse PDF–982K

Select item 111418773.

OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma

Trang T.T. Nguyen, Consuelo Torrini, Enyuan Shang, Chang Shu, Jeong-Yeon Mun, Qiuqiang Gao, Nelson Humala, Hasan O. Akman, Guoan Zhang, Mike-Andrew Westhoff, Georg Karpel-Massler, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin

JCI Insight. 2024 Apr 22; 9(8): e172565. Published online 2024 Mar 14. doi: 10.1172/jci.insight.172565

PMCID:: PMC11141877

Abstract Article PDF–7.3M

Select item 99052854.

Biallelic variants in OGDH encoding oxoglutarate dehydrogenase lead to a neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities

Ella F. Whittle, Madison Chilian, Ehsan Ghayoor Karimiani, Helga Progri, Daniela Buhas, Melis Kose, Rebecca D. Ganetzky, Mehran Beiraghi Toosi, Paria Najarzadeh Torbati, Reza Shervin Badv, Ivan Shelihan, Hui Yang, Houda Zghal Elloumi, Sukyeong Lee, Yalda Jamshidi, Alan M. Pittman, Henry Houlden, Erika Ignatius, Shamima Rahman, Reza Maroofian, Wan Hee Yoon, Christopher J. Carroll

Genet Med. 2023 Feb; 25(2): 100332. doi: 10.1016/j.gim.2022.11.001

PMCID:: PMC9905285

Abstract Article

Select item 76479565.

A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease

Zheng Yie Yap, Klaudia Strucinska, Satoshi Matsuzaki, Sukyeong Lee, Yue Si, Kenneth Humphries, Mark A. Tarnopolsky, Wan Hee Yoon

J Inherit Metab Dis. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: J Inherit Metab Dis. 2021 Mar; 44(2): 388–400. Published online 2020 Jun 24. doi: 10.1002/jimd.12248

PMCID:: PMC7647956

Abstract Article PDF–813K

Select item 61012006.

Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression

Richard M. Denton, Timothy J. Pullen, Craig T. Armstrong, Kate J. Heesom, Guy A. Rutter

Biochem J. Author manuscript; available in PMC 2018 Aug 20.

Published in final edited form as: Biochem J. 2016 May 1; 473(9): 1165–1178. Published online 2016 Mar 2. doi: 10.1042/BCJ20160135

PMCID:: PMC6101200

Abstract Article PDF–3.1M

Select item 54107817.

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

Nina Ilic, Kıvanç Birsoy, Andrew J. Aguirre, Nora Kory, Michael E. Pacold, Shambhavi Singh, Susan E. Moody, Joseph D. DeAngelo, Nicole A. Spardy, Elizaveta Freinkman, Barbara A. Weir, Aviad Tsherniak, Glenn S. Cowley, David E. Root, John M. Asara, Francisca Vazquez, Hans R. Widlund, David M. Sabatini, William C. Hahn

Proc Natl Acad Sci U S A. 2017 Apr 25; 114(17): E3434–E3443. Published online 2017 Apr 10. doi: 10.1073/pnas.1617922114

PMCID:: PMC5410781

Abstract Article PDF–2.0M

Select item 51337068.

Amplification of USP13 drives ovarian cancer metabolism

Cecil Han, Lifeng Yang, Hyun Ho Choi, Joelle Baddour, Abhinav Achreja, Yunhua Liu, Yujing Li, Jiada Li, Guohui Wan, Cheng Huang, Guang Ji, Xinna Zhang, Deepak Nagrath, Xiongbin Lu

Nat Commun. 2016; 7: 13525. Published online 2016 Nov 28. doi: 10.1038/ncomms13525

PMCID:: PMC5133706

Abstract Article PDF–2.7M

Select item 51063739.

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

Stephen P. Burr, Ana S.H. Costa, Guinevere L. Grice, Richard T. Timms, Ian T. Lobb, Peter Freisinger, Roger B. Dodd, Gordon Dougan, Paul J. Lehner, Christian Frezza, James A. Nathan

Cell Metab. 2016 Nov 8; 24(5): 740–752. doi: 10.1016/j.cmet.2016.09.015

PMCID:: PMC5106373

Abstract Article

Select item 332109910.

Deficits in the Mitochondrial Enzyme α-Ketoglutarate Dehydrogenase Lead to Alzheimer’s Disease-like Calcium Dysregulation

Gary E. Gibson, Huan-Lian Chen, Hui Xu, Linghua Qiu, Zuoshang Xu, Travis T. Denton, Qingli Shi

Neurobiol Aging. Author manuscript; available in PMC 2013 Jun 1.

Published in final edited form as: Neurobiol Aging. 2012 Jun; 33(6): 1121.e13–1121.e24. Published online 2011 Dec 14. doi: 10.1016/j.neurobiolaging.2011.11.003

PMCID:: PMC3321099

Abstract Article PDF–339K

Select item 720684911.

DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo

João Leandro, Tetyana Dodatko, Jan Aten, Natalia S Nemeria, Xu Zhang, Frank Jordan, Ronald C Hendrickson, Roberto Sanchez, Chunli Yu, Robert J DeVita, Sander M Houten

Hum Mol Genet. 2020 May 8; 29(7): 1168–1179. Published online 2020 Mar 11. doi: 10.1093/hmg/ddaa037

PMCID:: PMC7206849

Abstract Article PDF–1.0M

Select item 700248812.

Synthetic analogues of 2-oxo acids discriminate metabolic contribution of the 2-oxoglutarate and 2-oxoadipate dehydrogenases in mammalian cells and tissues

Artem V. Artiukhov, Aneta Grabarska, Ewelina Gumbarewicz, Vasily A. Aleshin, Thilo Kähne, Toshihiro Obata, Alexey V. Kazantsev, Nikolay V. Lukashev, Andrzej Stepulak, Alisdair R. Fernie, Victoria I. Bunik

Sci Rep. 2020; 10: 1886. Published online 2020 Feb 5. doi: 10.1038/s41598-020-58701-4

PMCID:: PMC7002488

Abstract Article PDF–6.2M

Select item 365935513.

The negative impact of α-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation

Gergely Kiss, Csaba Konrad, Judit Doczi, Anatoly A. Starkov, Hibiki Kawamata, Giovanni Manfredi, Steven F. Zhang, Gary E. Gibson, M. Flint Beal, Vera Adam-Vizi, Christos Chinopoulos

FASEB J. 2013 Jun; 27(6): 2392–2406. doi: 10.1096/fj.12-220202

PMCID:: PMC3659355

Abstract Article

Select item 584145214.

KAT2A coupled with the a-KGDH complex acts as a histone H3 succinyltransferase

Yugang Wang, Yusong R. Guo, Ke Liu, Zheng Yin, Rui Liu, Yan Xia, Lin Tan, Peiying Yang, Jong-Ho Lee, Xin-jian Li, David Hawke, Yanhua Zheng, Xu Qian, Jianxin Lyu, Jie He, Dongming Xing, Yizhi Jane Tao, Zhimin Lu

Nature. Author manuscript; available in PMC 2018 Mar 7.

Published in final edited form as: Nature. 2017 Dec 14; 552(7684): 273–277. Published online 2017 Dec 6. doi: 10.1038/nature25003

PMCID:: PMC5841452

Abstract Article PDF–3.7M

Select item 400273415.

Yeast two-hybrid screening of proteins interacting with plasmin receptor subunit: C-terminal fragment of annexin A2

Qun Li, Yves Laumonnier, Tatiana Syrovets, Thomas Simmet

Acta Pharmacol Sin. 2011 Nov; 32(11): 1411–1418. Published online 2011 Oct 3. doi: 10.1038/aps.2011.121

PMCID:: PMC4002734

Abstract Article PDF–1.2M

Select item 189600716.

Discovery of tissue-specific exons using comprehensive human exon microarrays

Tyson A Clark, Anthony C Schweitzer, Tina X Chen, Michelle K Staples, Gang Lu, Hui Wang, Alan Williams, John E Blume

Genome Biol. 2007; 8(4): R64. Published online 2007 Apr 24. doi: 10.1186/gb-2007-8-4-r64

PMCID:: PMC1896007

Abstract Article PDF–565K

Select item 569108317.

Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Alice C. Newman, Alain J. Kemp, Yvette Drabsch, Christian Behrends, Simon Wilkinson

Nat Commun. 2017; 8: 1537. Published online 2017 Nov 16. doi: 10.1038/s41467-017-00859-z

PMCID:: PMC5691083

Abstract Article PDF–2.3M

Select item 636853918.

A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration

João P. L. Coelho, Matthias Stahl, Nicolas Bloemeke, Kevin Meighen-Berger, Carlos Piedrafita Alvira, Zai-Rong Zhang, Stephan A. Sieber, Matthias J. Feige

Nat Commun. 2019; 10: 672. Published online 2019 Feb 8. doi: 10.1038/s41467-019-08632-0