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Select item 79161351.

Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism

Juan José Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andrés Ernesto Zucchetti

Cells. 2021 Feb; 10(2): 359. Published online 2021 Feb 9. doi: 10.3390/cells10020359

PMCID:: PMC7916135

Abstract Article PDF–3.3M

Select item 76697162.

The Membrane Proximal Proline-Rich Region and Correct Order of C-Terminal Tyrosines on the Adaptor Protein LAT Are Required For TCR-Mediated Signaling and Downstream Functions

Mikaela M. Tremblay, Tomye Ollinger, Jon C.D. Houtman

Cell Signal. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Cell Signal. 2020 Dec; 76: 109790. Published online 2020 Sep 23. doi: 10.1016/j.cellsig.2020.109790

PMCID:: PMC7669716

Abstract Article PDF–1.0M

Select item 59641203.

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Lakshmi Balagopalan, Jason Yi, Tiffany Nguyen, Katherine M. McIntire, Adam S. Harned, Kedar Narayan, Lawrence E. Samelson

Nat Commun. 2018; 9: 2013. Published online 2018 May 22. doi: 10.1038/s41467-018-04419-x

PMCID:: PMC5964120

Abstract Article PDF–7.9M

Select item 56475114.

Dynamic Scaling Analysis of Molecular Motion within the LAT:Grb2:SOS Protein Network on Membranes

William Y.C. Huang, Han-Kuei Chiang, Jay T. Groves

Biophys J. 2017 Oct 17; 113(8): 1807–1813. Published online 2017 Oct 17. doi: 10.1016/j.bpj.2017.08.024

PMCID:: PMC5647511

Abstract Article PDF–1.1M

Select item 49611185.

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS

William Y. C. Huang, Qingrong Yan, Wan-Chen Lin, Jean K. Chung, Scott D. Hansen, Sune M. Christensen, Hsiung-Lin Tu, John Kuriyan, Jay T. Groves

Proc Natl Acad Sci U S A. 2016 Jul 19; 113(29): 8218–8223. Published online 2016 Jul 1. doi: 10.1073/pnas.1602602113

PMCID:: PMC4961118

Abstract Article PDF–2.1M

Select item 49250126.

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT

Baerbel Keller, Irina Zaidman, O. Sascha Yousefi, Dov Hershkovitz, Jerry Stein, Susanne Unger, Kristina Schachtrup, Mikael Sigvardsson, Amir A. Kuperman, Avraham Shaag, Wolfgang W. Schamel, Orly Elpeleg, Klaus Warnatz, Polina Stepensky

J Exp Med. 2016 Jun 27; 213(7): 1185–1199. doi: 10.1084/jem.20151110

Correction in:: J Exp Med. 2017 Jul 3; 214(7): 2165.

PMCID:: PMC4925012

Abstract Article PDF–2.2M

Select item 41444497.

Cell surface LAT is recruited to microclusters and is active in signaling

Lakshmi Balagopalan, Valarie A. Barr, Robert L. Kortum, Anna K. Park, Lawrence E. Samelson

J Immunol. Author manuscript; available in PMC 2014 Aug 26.

Published in final edited form as: J Immunol. 2013 Apr 15; 190(8): 3849–3853. Published online 2013 Mar 13. doi: 10.4049/jimmunol.1202760

PMCID:: PMC4144449

Abstract Article PDF–606K

Select item 35550938.

Enhanced Function of Redirected Human T Cells Expressing Linker for Activation of T Cells That Is Resistant to Ubiquitylation

Naoki Kunii, Yangbing Zhao, Shuguang Jiang, Xiaojun Liu, John Scholler, Lakshmi Balagopalan, Lawrence E. Samelson, Michael C. Milone, Carl H. June

Hum Gene Ther. 2013 Jan; 24(1): 27–37. Published online 2012 Sep 21. doi: 10.1089/hum.2012.130

PMCID:: PMC3555093

Abstract Article PDF–729K

Select item 30411399.

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

Lakshmi Balagopalan, Benjamin A. Ashwell, Kelsie M. Bernot, Itoro O. Akpan, Naeha Quasba, Valarie A. Barr, Lawrence E. Samelson

Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7): 2885–2890. Published online 2011 Jan 31. doi: 10.1073/pnas.1007098108

PMCID:: PMC3041139

Abstract Article PDF–1.2M

Select item 217274910.

Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation

Natsuko Tanimura, Masakazu Nagafuku, Yasuko Minaki, Yukio Umeda, Fumie Hayashi, Junko Sakakura, Akiko Kato, Douglas R. Liddicoat, Masato Ogata, Toshiyuki Hamaoka, Atsushi Kosugi

J Cell Biol. 2003 Jan 6; 160(1): 125–135. doi: 10.1083/jcb.200207096

PMCID:: PMC2172749

Abstract Article PDF–4.2M

Select item 13973211.

Effect of Redox Balance Alterations on Cellular Localization of LAT and Downstream T-Cell Receptor Signaling Pathways

Sonja I. Gringhuis, Ellen A. M. Papendrecht-van der Voort, Angela Leow, E. W. Nivine Levarht, Ferdinand C. Breedveld, Cornelis L. Verweij

Mol Cell Biol. 2002 Jan; 22(2): 400–411. doi: 10.1128/MCB.22.2.400-411.2002

PMCID:: PMC139732

Abstract Article PDF–352K

Select item 791531212.

A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for Combined Analysis of Early TCR Signaling

Inmaculada Vico-Barranco, Mikel M. Arbulo-Echevarria, Isabel Serrano-García, Alba Pérez-Linaza, José M. Miranda-Sayago, Arkadiusz Miazek, Isaac Narbona-Sánchez, Enrique Aguado

Cells. 2021 Feb; 10(2): 343. Published online 2021 Feb 6. doi: 10.3390/cells10020343

PMCID:: PMC7915312

Abstract Article PDF–2.3M

Select item 520102113.

Development of nanoscale structure in LAT-based signaling complexes

Valarie A. Barr, Eilon Sherman, Jason Yi, Itoro Akpan, Alexandre K. Rouquette-Jazdanian, Lawrence E. Samelson

J Cell Sci. 2016 Dec 15; 129(24): 4548–4562. doi: 10.1242/jcs.194886

PMCID:: PMC5201021

Abstract Article

Select item 359821814.

Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma

Cheng-ye Li, Juan Peng, Lian-pin Ren, Li-xing Gan, Xiao-jiong Lu, Qian Liu, Wen Gu, Xue-jun Guo

J Transl Med. 2013; 11: 26. Published online 2013 Jan 30. doi: 10.1186/1479-5876-11-26

PMCID:: PMC3598218

Abstract Article PDF–1.2M

Select item 299489315.

T Cell Receptor Signal Initiation Induced by Low-Grade Stimulation Requires the Cooperation of LAT in Human T Cells

Shen Dong, Béatrice Corre, Konstantina Nika, Sandra Pellegrini, Frédérique Michel

PLoS One. 2010; 5(11): e15114. Published online 2010 Nov 30. doi: 10.1371/journal.pone.0015114

PMCID:: PMC2994893

Abstract Article PDF–1.5M

Select item 221303616.

The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation

Christiane Gerke, Stanley Falkow, Yueh-hsiu Chien

J Exp Med. 2005 Feb 7; 201(3): 361–371. doi: 10.1084/jem.20041120

PMCID:: PMC2213036

Abstract Article PDF–2.5M

Select item 221221017.

Molecular Cloning of the cDNA Encoding pp36, a Tyrosine-phosphorylated Adaptor Protein Selectively Expressed by T Cells and Natural Killer Cells

John R. Weber, Sigurd Ørstavik, Knut Martin Torgersen, Niels Christian Danbolt, Siri F. Berg, James C. Ryan, Kjetil Taskén, John B. Imboden, John T. Vaage

J Exp Med. 1998 Apr 6; 187(7): 1157–1161. doi: 10.1084/jem.187.7.1157

PMCID:: PMC2212210

Abstract Article PDF–140K

Select item 138224418.

Regulation of the human LAT gene by the Elf-1 transcription factor

Timothy S Finco, Geri E Justice-Healy, Shivani J Patel, Victoria E Hamilton

BMC Mol Biol. 2006; 7: 4. Published online 2006 Feb 7. doi: 10.1186/1471-2199-7-4

PMCID:: PMC1382244

Abstract Article PDF–750K

Select item 39107319.

Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads

Sangwoo Cho, C Alejandro Velikovsky, Chittoor P Swaminathan, Jon C D Houtman, Lawrence E Samelson, Roy A Mariuzza

EMBO J. 2004 Apr 7; 23(7): 1441–1451. Published online 2004 Mar 18. doi: 10.1038/sj.emboj.7600168

PMCID:: PMC391073

Abstract Article PDF–512K

Select item 1115921420.

Prognostic significance of L‐type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung

Kyoichi Kaira, Noboru Oriuchi, Hisao Imai, Kimihiro Shimizu, Noriko Yanagitani, Noriaki Sunaga, Takeshi Hisada, Tamotsu Ishizuka, Yoshikatsu Kanai, Hitoshi Endou, Takashi Nakajima, Masatomo Mori

Cancer Sci. 2009 Feb; 100(2): 249–254. Published online 2008 Dec 5. doi: 10.1111/j.1349-7006.2008.01029.x

PMCID:: PMC11159214

Abstract Article PDF–323K

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PMC Links for Gene (Select 27040) (68)
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Pavona cactus 18S ribosomal RNA gene, partial sequence
Pavona cactus 18S ribosomal RNA gene, partial sequence
gi|1089675909|gb|KU921632.1|

Nucleotide
Pavona cactus genomic DNA sequence contains 5.8S rRNA gene, ITS2 and 28S rRNA ge...
Pavona cactus genomic DNA sequence contains 5.8S rRNA gene, ITS2 and 28S rRNA gene, strain SA1250
gi|1253553407|emb|LT630925.1|

Nucleotide
Homo sapiens mRNA for tyrosine phosphatase, complete cds
Homo sapiens mRNA for tyrosine phosphatase, complete cds
gi|984624|dbj|D64053.1|HUMPTPAA

Nucleotide
Related BioAssays, by Target Similarity (List) for PubChem BioAss... (59)
Related BioAssays, by Target Similarity (List) for PubChem BioAssay (Select 1646483)
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