Volume 7(4); 2024 Apr 12
Articles from this journal are generally available in PMC after a 12-month delay (embargo); however, the delay may vary at the discretion of the publisher.
Reviews
Updates on Overcoming Bicalutamide Resistance: A Glimpse
into Resistance to a Novel Antiandrogen
Mehrnaz Izady, Fatemeh Khatami, Zeinab Ahadi, Hassan Roudgari, Seyed Mohammad Kazem Aghamir
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 905–914. Published online 2024 Mar 7. doi: 10.1021/acsptsci.3c00299
- PMCID:
- PMC11020064
Currently embargoed: Free in PMC on Mar 7, 2025; PubMed
Drug Repurposing: A Leading Strategy for New Threats
and Targets
Ashish
Sriram Mishra, Manimaran Vasanthan, Sivakumar Ponnurengam Malliappan
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 915–932. Published online 2024 Apr 1. doi: 10.1021/acsptsci.3c00361
- PMCID:
- PMC11019736
Currently embargoed: Free in PMC on Apr 1, 2025; PubMed
Recommended Tool Compounds for Modifying the Cystic
Fibrosis Transmembrane Conductance Regulator Channel Variants
XiaoXuan Han, Danni Li, Yimin Zhu, Elena K. Schneider-Futschik
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 933–950. Published online 2024 Mar 14. doi: 10.1021/acsptsci.3c00362
- PMCID:
- PMC11019735
Currently embargoed: Free in PMC on Mar 14, 2025; PubMed
Migraine and Its
Treatment from the Medicinal Chemistry
Perspective
Ezgi Pehlivanlar, Simone Carradori, Rahime Simsek
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 951–966. Published online 2024 Mar 16. doi: 10.1021/acsptsci.3c00370
- PMCID:
- PMC11020076
Currently embargoed: Free in PMC on Mar 16, 2025; PubMed
Advances in Precision
Medicine Approaches for Colorectal
Cancer: From Molecular Profiling to Targeted Therapies
Neelakanta
Sarvashiva Kiran, Chandrashekar Yashaswini, Rahul Maheshwari, Sankha Bhattacharya, Bhupendra G. Prajapati
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 967–990. Published online 2024 Mar 19. doi: 10.1021/acsptsci.4c00008
- PMCID:
- PMC11019743
Currently embargoed: Free in PMC on Mar 19, 2025; PubMed
Articles
Santacruzamate
A Alleviates Pain and Pain-Related
Adverse Emotions through the Inhibition of Microglial Activation in
the Anterior Cingulate Cortex
Yan Qin, Qingqing Liu, Saiying Wang, Qinhui Wang, Yaya Du, Jingyue Yao, Yue Chen, Qi Yang, Yumei Wu, Shuibing Liu, Minggao Zhao, Gaofei Wei, Le Yang
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1002–1012. Published online 2024 Feb 16. doi: 10.1021/acsptsci.3c00282
- PMCID:
- PMC11019733
Currently embargoed: Free in PMC on Feb 16, 2025; PubMed
Polydopamine-Based
Resveratrol-Hyaluronidase Nanomedicine
Inhibited Pancreatic Cancer Cell Invasive Phenotype in Hyaluronic
Acid Enrichment Tumor Sphere Model
Shuo Yu, Lu Zhang, Yanshen Yang, Meijuan Wang, Tingting Liu, Wenwen Ji, Yang Liu, Hao Lv, Yang Zhao, Xi Chen, Tinghua Hu
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1013–1022. Published online 2024 Jan 15. doi: 10.1021/acsptsci.3c00304
- PMCID:
- PMC11020062
Currently embargoed: Free in PMC on Jan 15, 2025; PubMed
Napyradiomycin
B4 Suppresses RANKL-Induced Osteoclastogenesis
and Prevents Alveolar Bone Destruction in Experimental Periodontitis
Ju Ang Kim, Soomin Lim, Geum Jin Kim, Velina Silviani, Jung-Eun Kim, Jong-Sup Bae, Joo-Won Nam, Hyukjae Choi, Eui Kyun Park
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1023–1031. Published online 2024 Apr 3. doi: 10.1021/acsptsci.3c00315
- PMCID:
- PMC11019734
Currently embargoed: Free in PMC on Apr 3, 2025; PubMed
Screening Peptide
Drug Candidates To Neutralize Whole
Viral Agents: A Case Study with Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2)
Cemile
Elif Özçelik, Cemre Zekiye Araz, Özgür Yılmaz, Sevgi Gülyüz, Pınar Özdamar, Ezgi Salmanlı, Aykut Özkul, Urartu Özgür Şafak Şeker
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1032–1042. Published online 2024 Mar 21. doi: 10.1021/acsptsci.3c00317
- PMCID:
- PMC11020059
Currently embargoed: Free in PMC on Mar 21, 2025; PubMed
Hi1a Improves Sensorimotor Deficit following Endothelin-1-Induced Stroke in
Rats but Does Not Improve Functional Outcomes following Filament-Induced Stroke in
Mice
Adriana Knezic, Elena Budusan, Natalie J. Saez, Brad R. S. Broughton, Lachlan D. Rash, Glenn F. King, Robert E. Widdop, Claudia A. McCarthy
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1043–1054. Published online 2024 Mar 14. doi: 10.1021/acsptsci.3c00328
- PMCID:
- PMC11022283
Currently embargoed: Free in PMC on Mar 14, 2025; PubMed
Immunoactivation
by Cutaneous Blue Light Irradiation
Inhibits Remote Tumor Growth and Metastasis
Yingchun Yang, Rong Yang, Fangqing Deng, Luqiu Yang, Guanghao Yang, Yanyan Liu, Qing Tian, Zixi Wang, Aipeng Li, Li Shang, Genyang Cheng, Lianbing Zhang
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1055–1068. Published online 2024 Mar 16. doi: 10.1021/acsptsci.3c00355
- PMCID:
- PMC11019738
Currently embargoed: Free in PMC on Mar 16, 2025; PubMed
Expanding the Chemical
Space of Transforming Growth
Factor-β (TGFβ) Receptor Type II Degraders with
3,4-Disubstituted Indole Derivatives
Daniel Längle, Stephanie Wojtowicz-Piotrowski, Till Priegann, Niklas Keller, Fabian Wesseler, Elena S. Reckzeh, Karsten Steffens, Christoph Grathwol, Jana Lemke, Maren Flasshoff, Christian Näther, Anna C. Jonson, Andreas Link, Oliver Koch, Gianni M. Di Guglielmo, Dennis Schade
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1069–1085. Published online 2024 Mar 21. doi: 10.1021/acsptsci.3c00371
- PMCID:
- PMC11020067
Currently embargoed: Free in PMC on Mar 21, 2025; PubMed
Discovery of Protease-Activated
Receptor 4 (PAR4)-Tethered
Ligand Antagonists Using Ultralarge Virtual Screening
Shannon
T. Smith, Jackson B. Cassada, Lukas Von Bredow, Kevin Erreger, Emma M. Webb, Trevor A. Trombley, Jacob J. Kalbfleisch, Brian J. Bender, Irene Zagol-Ikapitte, Valerie M. Kramlinger, Jacob L. Bouchard, Sidnee G. Mitchell, Maik Tretbar, Brian K. Shoichet, Craig W. Lindsley, Jens Meiler, Heidi E. Hamm
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1086–1100. Published online 2024 Mar 21. doi: 10.1021/acsptsci.3c00378
- PMCID:
- PMC11020070
Currently embargoed: Free in PMC on Mar 21, 2025; PubMed
Photodynamic Therapy
of LD4-Photosensitizer Attenuates
the Acute Pneumonia Induced by Klebsiella pneumoniae
Zhuo Tao, Xin Li, Hongzhi Yu, Junping Wu, Ying Wen, Tianjun Liu
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1101–1113. Published online 2024 Mar 5. doi: 10.1021/acsptsci.3c00392
- PMCID:
- PMC11020065
Currently embargoed: Free in PMC on Mar 5, 2025; PubMed
Incorporation of
Three Extracyclic Arginine Residues
into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro])
Decreases Food Intake When Administered Intrathecally or Subcutaneously
Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues
(c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]
Mark D. Ericson, Katie T. Freeman, Courtney M. Larson, Jacob L. Bouchard, Kristen John, Mary M. Lunzer, Zoe M. Koerperich, Carrie Haskell-Luevano
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1114–1125. Published online 2024 Apr 2. doi: 10.1021/acsptsci.4c00011
- PMCID:
- PMC11020072
Currently embargoed: Free in PMC on Apr 2, 2025; PubMed
Novel Peptide DR3penA
as a Low-Toxicity Antirenal
Fibrosis Agent by Suppressing the TGF-β1/miR-212-5p/Low-Density
Lipoprotein Receptor Class a Domain Containing 4/Smad Axis
Bochuan Deng, Jiao Zhang, Xiang Zhang, Dan Wang, Lu Cheng, Ping Su, Tingli Yu, Guangjun Bao, Guofeng Li, Liang Hong, Xiaokang Miao, Wenle Yang, Rui Wang, Junqiu Xie
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1126–1141. Published online 2024 Mar 14. doi: 10.1021/acsptsci.4c00010
- PMCID:
- PMC11020069
Currently embargoed: Free in PMC on Mar 14, 2025; PubMed
Illuminating Neuropeptide Y Y4 Receptor
Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity
as Novel Molecular Tools
Jakob Gleixner, Sergei Kopanchuk, Lukas Grätz, Maris-Johanna Tahk, Tõnis Laasfeld, Santa Veikšina, Carina Höring, Albert O. Gattor, Laura J. Humphrys, Christoph Müller, Nataliya Archipowa, Johannes Köckenberger, Markus R. Heinrich, Roger Jan Kutta, Ago Rinken, Max Keller
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1142–1168. Published online 2024 Mar 20. doi: 10.1021/acsptsci.4c00013
- PMCID:
- PMC11019746
Currently embargoed: Free in PMC on Mar 20, 2025; PubMed
Protein Corona Composition of Gold Nanocatalysts
Ali Akbar Ashkarran, Soheyl Tadjiki, Zijin Lin, Kylie Hilsen, Noor Ghazali, Sarah Krikor, Shahriar Sharifi, Meisam Asgari, Michael Hotchkin, Adam Dorfman, Karen S. Ho, Morteza Mahmoudi
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1169–1177. Published online 2024 Mar 14. doi: 10.1021/acsptsci.4c00028
- PMCID:
- PMC11020068
Currently embargoed: Free in PMC on Mar 14, 2025; PubMed
Novel BRD4-p53
Inhibitor SDU-071 Suppresses Proliferation
and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells
Shumei Wang, Kang Lei, Hsien-Tsung Lai, Tingting Liu, Lupei Du, Shwu-Yuan Wu, Xiaohan Ye, Cheng-Ming Chiang, Minyong Li
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1178–1190. Published online 2024 Mar 12. doi: 10.1021/acsptsci.4c00057
- PMCID:
- PMC11019737
Currently embargoed: Free in PMC on Mar 12, 2025; PubMed
Viewpoint
Digital Futures
of Learning Pharmacology and Medicinal
and Organic Chemistry
Fun Man Fung, Etienne Blanc, Xavier Coumoul
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1191–1194. Published online 2024 Mar 14. doi: 10.1021/acsptsci.4c00043
- PMCID:
- PMC11020058
Currently embargoed: Free in PMC on Mar 14, 2025; PubMed
Addition/Correction
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A. Laufer, Christa E. Müller, Michael Gütschow, Thanigaimalai Pillaiyar
ACS Pharmacol Transl Sci. 2024 Apr 12; 7(4): 1195–1196. Published online 2024 Mar 6. doi: 10.1021/acsptsci.4c00095
- PMCID:
- PMC11020060
Articles from ACS Pharmacology & Translational Science are provided here courtesy of American Chemical Society