Volume 177(24); 2020 Dec

TARGETING THE NITRIC OXIDE (NO)‐cGMP PATHWAY: THERAPEUTIC OPPORTUNITIES IN THE 21ST CENTURY

Nitric oxide signalling in the brain and its control of bodily functions

Konstantina Chachlaki, Vincent Prevot

Br J Pharmacol. 2020 Dec; 177(24): 5437–5458. Published online 2019 Sep 8. doi: 10.1111/bph.14800

PMCID:: PMC7707094

Article PDF–2.4M

NO and hepatocellular cancer

Ronghua Wang, David A. Geller, David A. Wink, Bin Cheng, Timothy R. Billiar

Br J Pharmacol. 2020 Dec; 177(24): 5459–5466. Published online 2019 Dec 11. doi: 10.1111/bph.14838

PMCID:: PMC7707086

Article PDF–1.8M

Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease

Nikolaos Tzoumas, Tariq E. Farrah, Neeraj Dhaun, David J. Webb

Br J Pharmacol. 2020 Dec; 177(24): 5467–5488. Published online 2020 Feb 4. doi: 10.1111/bph.14920

PMCID:: PMC7707100

Article PDF–5.6M

Review Articles

Function and therapeutic potential of G protein‐coupled receptors in epididymis

Daolai Zhang, Yanfei Wang, Hui Lin, Yujing Sun, Mingwei Wang, Yingli Jia, Xiao Yu, Hui Jiang, Wenming Xu, Jin‐Peng Sun, Zhigang Xu

Br J Pharmacol. 2020 Dec; 177(24): 5489–5508. Published online 2020 Oct 29. doi: 10.1111/bph.15252

PMCID:: PMC7707088

Article PDF–4.8M

Development of cannabidiol as a treatment for severe childhood epilepsies

Claire M. Williams, Gary J. Stephens

Br J Pharmacol. 2020 Dec; 177(24): 5509–5517. Published online 2020 Oct 27. doi: 10.1111/bph.15274

PMCID:: PMC7707087

Article PDF–1.6M

Research Papers

Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans

Rob C. van Wijk, Wanbin Hu, Sharka M. Dijkema, Dirk‐Jan van den Berg, Jeremy Liu, Rida Bahi, Fons J. Verbeek, Ulrika S.H. Simonsson, Herman P. Spaink, Piet H. van der Graaf, Elke H.J. Krekels

Br J Pharmacol. 2020 Dec; 177(24): 5518–5533. Published online 2020 Nov 3. doi: 10.1111/bph.15247

PMCID:: PMC7707096

Article PDF–11M

Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity

Leena Otsomaa, Jouko Levijoki, Gerd Wohlfahrt, Hugh Chapman, Ari‐Pekka Koivisto, Kaisa Syrjänen, Tuula Koskelainen, Saara‐Elisa Peltokorpi, Piet Finckenberg, Aira Heikkilä, Najah Abi‐Gerges, Andre Ghetti, Paul E. Miller, Guy Page, Eero Mervaala, Norbert Nagy, Zsófia Kohajda, Norbert Jost, László Virág, András Varró, Julius Gy. Papp

Br J Pharmacol. 2020 Dec; 177(24): 5534–5554. Published online 2020 Nov 10. doi: 10.1111/bph.15257

PMCID:: PMC7707092

Article PDF–14M

Preclinical studies investigating the neural mechanisms involved in the co‐morbidity of migraine and temporomandibular disorders: the role of CGRP

Simon Akerman, Marcela Romero‐Reyes

Br J Pharmacol. 2020 Dec; 177(24): 5555–5568. Published online 2020 Oct 21. doi: 10.1111/bph.15263

PMCID:: PMC7707098

Article PDF–17M

Methnaridine is an orally bioavailable, fast‐killing and long‐acting antimalarial agent that cures Plasmodium infections in mice

Weisi Wang, Junmin Yao, Zhuo Chen, Yiming Sun, Yuqing Shi, Yufen Wei, Hejun Zhou, Yingfang Yu, Shizhu Li, Liping Duan

Br J Pharmacol. 2020 Dec; 177(24): 5569–5579. Published online 2020 Oct 30. doi: 10.1111/bph.15268

PMCID:: PMC7707099

Article PDF–3.6M

Metabolic effects of carvedilol through β‐arrestin proteins: investigations in a streptozotocin‐induced diabetes rat model and in C2C12 myoblasts

Berna Güven, Zümra Kara, Arzu Onay‐Beşikci

Br J Pharmacol. 2020 Dec; 177(24): 5580–5594. Published online 2020 Nov 15. doi: 10.1111/bph.15269

Correction in:: Br J Pharmacol. 2021 Jun; 178(11): 2370.

PMCID:: PMC7707093

Article PDF–6.4M

Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors

Praveen Kumar, Petra Scholze, Martin Fronius, Gabriela Krasteva‐Christ, Monika I. Hollenhorst

Br J Pharmacol. 2020 Dec; 177(24): 5595–5608. Published online 2020 Nov 9. doi: 10.1111/bph.15270

PMCID:: PMC7707097

Article PDF–5.0M

Effects of mavacamten on Ca²⁺ sensitivity of contraction as sarcomere length varied in human myocardium

Peter O. Awinda, Yemeserach Bishaw, Marissa Watanabe, Maya A. Guglin, Kenneth S. Campbell, Bertrand C. W. Tanner

Br J Pharmacol. 2020 Dec; 177(24): 5609–5621. Published online 2020 Oct 21. doi: 10.1111/bph.15271

PMCID:: PMC7707091

Article PDF–2.9M

Rho kinase inhibitor fasudil reduces l‐DOPA‐induced dyskinesia in a rat model of Parkinson's disease

Andrea Lopez‐Lopez, Carmen M. Labandeira, Jose L. Labandeira‐Garcia, Ana Muñoz

Br J Pharmacol. 2020 Dec; 177(24): 5622–5641. Published online 2020 Nov 3. doi: 10.1111/bph.15275

PMCID:: PMC7707090

Article PDF–26M

Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel

Ya‐Kun Huang, Yu‐Gang Lu, Xin Zhao, Jing‐Bing Zhang, Feng‐Ming Zhang, Yong Chen, Ling‐Bo Bi, Jia‐Hui Gu, Zuo‐Jie Jiang, Xiao‐Man Wu, Qing‐Yi Li, Yanli Liu, Jian‐Xin Shen, Xing‐Jun Liu

Br J Pharmacol. 2020 Dec; 177(24): 5642–5657. Published online 2020 Nov 16. doi: 10.1111/bph.15284

PMCID:: PMC7707095

Article PDF–35M

Glycogen synthase kinase‐3 inhibition rescues sex‐dependent contextual fear memory deficit in human immunodeficiency virus‐1 transgenic mice

Shamsudheen Moidunny, Michael A. Benneyworth, David J. Titus, Eleonore Beurel, Udhghatri Kolli, Joyce Meints, Richa Jalodia, Sundaram Ramakrishnan, Coleen M. Atkins, Sabita Roy

Br J Pharmacol. 2020 Dec; 177(24): 5658–5676. Published online 2020 Nov 23. doi: 10.1111/bph.15288