Volume 86(12); 2020 Dec

Issue Highlights

Issue highlights

Br J Clin Pharmacol. 2020 Dec; 86(12): 2331–2332. Published online 2020 Nov 25. doi: 10.1111/bcp.14640

PMCID:: PMC7688548

Article PDF–235K

Editorial

Regulatory science: Regulation is too important to leave it to the regulators

Hubert G. Leufkens

Br J Clin Pharmacol. 2020 Dec; 86(12): 2333–2334. Published online 2019 Apr 10. doi: 10.1111/bcp.13917

PMCID:: PMC7688532

Article PDF–147K

Spotlight Commentary

Effect of pharmaceutical regulatory policy on health impact

Jennifer H. Martin

Br J Clin Pharmacol. 2020 Dec; 86(12): 2335–2337. Published online 2020 Jun 14. doi: 10.1111/bcp.14390

PMCID:: PMC7688524

Article PDF–348K

Original Articles

Risk assessment of using off‐label morphine sulfate in a population‐based retrospective cohort of opioid‐dependent patients

Célian Bertin, Jessica Delorme, Marie Riquelme, Hélène Peyrière, Georges Brousse, Alain Eschalier, Denis Ardid, Chouki Chenaf, Nicolas Authier

Br J Clin Pharmacol. 2020 Dec; 86(12): 2338–2348. Published online 2019 Aug 24. doi: 10.1111/bcp.14082

PMCID:: PMC7688539

Article PDF–794K

Real‐world evaluation of the impact of statin intensity on adherence and persistence to therapy: A Scottish population‐based study

Renata Cristina Rezende Macedo do Nascimento, Tanja Mueller, Brian Godman, Sean MacBride Stewart, Simon Hurding, Francisco de Assis Acurcio, Augusto Afonso Guerra Junior, Juliana Alvares Teodoro, Alec Morton, Marion Bennie, Amanj Kurdi

Br J Clin Pharmacol. 2020 Dec; 86(12): 2349–2361. Published online 2020 May 30. doi: 10.1111/bcp.14333

PMCID:: PMC7688536

Article PDF–1.1M

Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake

Anne Keunecke, Sven Hoefman, Henk‐Jan Drenth, Jochen Zisowsky, Adriaan Cleton, Bart A. Ploeger

Br J Clin Pharmacol. 2020 Dec; 86(12): 2362–2376. Published online 2020 Jun 10. doi: 10.1111/bcp.14334

PMCID:: PMC7688542

Article PDF–1.6M

Dutch trends in the use of potentially harmful medication during pregnancy

Eline Houben, Bernke te Winkel, Eric A. P. Steegers, Ron M. C. Herings

Br J Clin Pharmacol. 2020 Dec; 86(12): 2377–2392. Published online 2020 May 26. doi: 10.1111/bcp.14341

PMCID:: PMC7688525

Article PDF–1.3M

Reporting rates of adverse reactions to specialty care medicines exhibit a direct positive correlation with patient exposure: A lack of evidence for the Weber effect

Vikas Modgill, Léa Dormegny, David J. Lewis

Br J Clin Pharmacol. 2020 Dec; 86(12): 2393–2403. Published online 2020 May 28. doi: 10.1111/bcp.14342

PMCID:: PMC7688531

Article PDF–2.4M

Usefulness of therapeutic drug monitoring of rilpivirine and its relationship with virologic response and resistance in a cohort of naive and pretreated HIV‐infected patients

Nadège Néant, Minh Patrick Lê, Naïm Bouazza, Florence Gattacceca, Yazdan Yazdanpanah, Catherine Dhiver, Sylvie Bregigeon, Saadia Mokhtari, Gilles Peytavin, Catherine Tamalet, Diane Descamps, Bruno Lacarelle, Caroline Solas

Br J Clin Pharmacol. 2020 Dec; 86(12): 2404–2413. Published online 2020 Jun 1. doi: 10.1111/bcp.14344

PMCID:: PMC7688528

Article PDF–1.7M

Potentially inappropriate medication use and related hospital admissions in aged care residents: The impact of dementia

Tesfahun C. Eshetie, Greg Roberts, Tuan A. Nguyen, Marianne H. Gillam, Dorsa Maher, Lisa M. Kalisch Ellett

Br J Clin Pharmacol. 2020 Dec; 86(12): 2414–2423. Published online 2020 Jun 1. doi: 10.1111/bcp.14345

PMCID:: PMC7688547

Article PDF–790K

Bioequivalence of macitentan and tadalafil given as fixed‐dose combination or single‐component tablets in healthy subjects

Simon Grill, Shirin Bruderer, Patricia N. Sidharta, Mariya Antonova, Susanne Globig, James Carlson, Armin Schultz, Dénes Csonka

Br J Clin Pharmacol. 2020 Dec; 86(12): 2424–2434. Published online 2020 May 29. doi: 10.1111/bcp.14347

PMCID:: PMC7688529

Article PDF–1.0M

Pregabalin poisoning and rising recreational use: a retrospective observational series

Katherine Z. Isoardi, Gregory Polkinghorne, Keith Harris, Geoffrey K. Isbister

Br J Clin Pharmacol. 2020 Dec; 86(12): 2435–2440. Published online 2020 Jun 5. doi: 10.1111/bcp.14348

PMCID:: PMC7688538

Article PDF–709K

Effectiveness of a multicomponent pharmacist intervention at hospital discharge for drug‐related problems: A cluster randomised cross‐over trial

Xavier Pourrat, Clémence Leyrat, Benoît Allenet, Brigitte Bouzige, Armelle Develay, Martial Fraysse, Valérie Garnier, Jean‐Michel Halimi, Clarisse Roux‐Marson, Bruno Giraudeau

Br J Clin Pharmacol. 2020 Dec; 86(12): 2441–2454. Published online 2020 Jun 7. doi: 10.1111/bcp.14349

PMCID:: PMC7688527

Article PDF–8.7M

Association of different oral anticoagulants use with renal function worsening in patients with atrial fibrillation: A multicentre cohort study

Daniele Pastori, Evaristo Ettorre, Gregory Y.H. Lip, Angela Sciacqua, Francesco Perticone, Francesco Melillo, Cosmo Godino, Rossella Marcucci, Martina Berteotti, Francesco Violi, Pasquale Pignatelli, Mirella Saliola, Danilo Menichelli, Marco Antonio Casciaro, Vito Menafra

Br J Clin Pharmacol. 2020 Dec; 86(12): 2455–2463. Published online 2020 Jun 7. doi: 10.1111/bcp.14350

PMCID:: PMC7688543

Article PDF–1.4M

Drug monitoring for mycophenolic acid in graft‐vs‐host disease prophylaxis in cord blood transplantation

Hiroyuki Muranushi, Junya Kanda, Yasuyuki Arai, Takero Shindo, Masakatsu Hishizawa, Takashi Yamamoto, Tadakazu Kondo, Kohei Yamashita, Kazuo Matsubara, Akifumi Takaori‐Kondo

Br J Clin Pharmacol. 2020 Dec; 86(12): 2464–2472. Published online 2020 May 30. doi: 10.1111/bcp.14354

PMCID:: PMC7688537

Article PDF–1.5M

Impact of granulocyte colony‐stimulating factor on FOLFIRINOX‐induced neutropenia prevention: A population pharmacokinetic/pharmacodynamic approach

Pauline Macaire, Justine Paris, Julie Vincent, François Ghiringhelli, Leïla Bengrine‐Lefevre, Antonin Schmitt

Br J Clin Pharmacol. 2020 Dec; 86(12): 2473–2485. Published online 2020 Jun 5. doi: 10.1111/bcp.14356

PMCID:: PMC7688541

Article PDF–4.5M

A pharmacokinetic‐pharmacodynamic study of a single dose of febuxostat in healthy subjects

Bishoy Kamel, Garry G. Graham, Sophie L. Stocker, Zhixin Liu, Kenneth M. Williams, Jane E. Carland, Kevin D. Pile, Richard O. Day

Br J Clin Pharmacol. 2020 Dec; 86(12): 2486–2496. Published online 2020 Jun 18. doi: 10.1111/bcp.14357

PMCID:: PMC7688545

Article PDF–2.2M

Prospective validation of a model‐informed precision dosing tool for vancomycin in intensive care patients

Rob ter Heine, Ron J. Keizer, Krista van Steeg, Elise J. Smolders, Matthijs van Luin, Hieronymus J. Derijks, Cornelis P.C. de Jager, Tim Frenzel, Roger Brüggemann

Br J Clin Pharmacol. 2020 Dec; 86(12): 2497–2506. Published online 2020 Jun 5. doi: 10.1111/bcp.14360

PMCID:: PMC7688533

Article PDF–1.0M

The first‐in‐human study of CNTO 7160, an anti‐interleukin‐33 receptor monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis

Ivo Nnane, Bart Frederick, Zhenling Yao, Donald Raible, Cathye Shu, Philipp Badorrek, Maarten van den Boer, Patrick Branigan, Karen Duffy, Frédéric Baribaud, Damien Fink, Tong‐Yuan Yang, Zhenhua Xu

Br J Clin Pharmacol. 2020 Dec; 86(12): 2507–2518. Published online 2020 Jun 14. doi: 10.1111/bcp.14361

PMCID:: PMC7688540

Article PDF–2.2M

Major bleeding risk associated with oral anticoagulant in real clinical practice. A multicentre 3‐year period population‐based prospective cohort study

Jacques Bouget, Frédéric Balusson, Maxime Maignan, Laure Pavageau, Pierre‐Marie Roy, Karine Lacut, Lucie‐Marie Scailteux, Emmanuel Nowak, Emmanuel Oger

Br J Clin Pharmacol. 2020 Dec; 86(12): 2519–2529. Published online 2020 Jun 1. doi: 10.1111/bcp.14362

PMCID:: PMC7688535

Article PDF–3.7M

Short Report

Regulatory Science and Innovation Programme for Europe (ReScIPE): A proposed model

Philip A. Hines, Richard H. Guy, Angela Brand, Anthony J. Humphreys, Marisa Papaluca‐Amati

Br J Clin Pharmacol. 2020 Dec; 86(12): 2530–2534. Published online 2019 Oct 17. doi: 10.1111/bcp.14099

PMCID:: PMC7688530

Article PDF–773K

Letters to the Editor

Why dose adjust systemic exposure when looking for associations with adverse events in tacrolimus‐treated transplant recipients?

Ida Robertsen, Jean‐Baptiste Woillard, Anders Åsberg

Br J Clin Pharmacol. 2020 Dec; 86(12): 2535. Published online 2019 May 29. doi: 10.1111/bcp.13984

PMCID:: PMC7688523

Article PDF–189K

Problems with paper entitled The impact of tacrolimus exposure on extrarenal adverse effects in adult transplant recipients

Terry E. Jones

Br J Clin Pharmacol. 2020 Dec; 86(12): 2536–2537. Published online 2019 Dec 17. doi: 10.1111/bcp.14106

PMCID:: PMC7688521

Article PDF–244K

Statins and glycaemic control in type 2 diabetes: Are bile acids relevant?

Daniel J. Sansome, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Tongzhi Wu

Br J Clin Pharmacol. 2020 Dec; 86(12): 2538–2539. Published online 2020 Mar 30. doi: 10.1111/bcp.14274

PMCID:: PMC7688544

Article PDF–227K

Response to ‘comment on “associations of statin use with glycemic traits and incident type 2 diabetes”’

Fariba Ahmadizar, Bruno H. Stricker

Br J Clin Pharmacol. 2020 Dec; 86(12): 2540–2541. Published online 2020 May 22. doi: 10.1111/bcp.14323

PMCID:: PMC7688546

Article PDF–220K

Identifying lithium‐poisoned patients who may benefit from haemodialysis remains highly challenging

Dominique Vodovar, Minh P. Lê, Laurence Labat, Bruno Mégarbane

Br J Clin Pharmacol. 2020 Dec; 86(12): 2542–2543. Published online 2020 Jun 2. doi: 10.1111/bcp.14366

PMCID:: PMC7688526

Article PDF–231K

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society