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Select item 75095791.

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E₂ Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions

Xavier Norel, Yukihiko Sugimoto, Gulsev Ozen, Heba Abdelazeem, Yasmine Amgoud, Amel Bouhadoun, Wesam Bassiouni, Marie Goepp, Salma Mani, Hasanga D. Manikpurage, Amira Senbel, Dan Longrois, Akos Heinemann, Chengcan Yao, Lucie H. Clapp

Pharmacol Rev. 2020 Oct; 72(4): 910–968. Published online 2020 Oct. doi: 10.1124/pr.120.019331

PMCID:: PMC7509579

Abstract Article PDF–737K

Select item 79680462.

17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin

Andrea L. Frump, Marjorie Albrecht, Bakhtiyor Yakubov, Sandra Breuils-Bonnet, Valérie Nadeau, Eve Tremblay, Francois Potus, Junichi Omura, Todd Cook, Amanda Fisher, Brooke Rodriguez, R. Dale Brown, Kurt R. Stenmark, C. Dustin Rubinstein, Kathy Krentz, Diana M. Tabima, Rongbo Li, Xin Sun, Naomi C. Chesler, Steeve Provencher, Sebastien Bonnet, Tim Lahm

J Clin Invest. 2021 Mar 15; 131(6): e129433. Published online 2021 Mar 15. doi: 10.1172/JCI129433

PMCID:: PMC7968046

Abstract Article PDF–11M

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Conformational changes in Chikungunya virus E2 protein upon heparan sulfate receptor binding explain mechanism of E2–E1 dissociation during viral entry

Bibekananda Sahoo, Tirumala Kumar Chowdary

Biosci Rep. 2019 Jun 28; 39(6): BSR20191077. Prepublished online 2019 Jun 5. Published online 2019 Jun 28. doi: 10.1042/BSR20191077

PMCID:: PMC6597851

Abstract Article PDF–2.1M

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Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during Mitosis

Apurva T. Prabhakar, Claire D. James, Dipon Das, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Iain M. Morgan

J Virol. 2022 Aug; 96(16): e00830-22. Published online 2022 Jul 26. doi: 10.1128/jvi.00830-22

PMCID:: PMC9400484

Abstract Article PDF–4.2M

Select item 75058155.

Estrogen receptor alpha (ERα)–mediated coregulator binding and gene expression discriminates the toxic ERα agonist diethylstilbestrol (DES) from the endogenous ERα agonist 17β-estradiol (E2)

Aziza Hussein Bakheit Adam, Laura H. J. de Haan, Ignacio Miro Estruch, Guido J. E. J. Hooiveld, Jochem Louisse, Ivonne M. C. M. Rietjens

Cell Biol Toxicol. 2020; 36(5): 417–435. Published online 2020 Feb 22. doi: 10.1007/s10565-020-09516-6

PMCID:: PMC7505815

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Select item 85465396.

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan

mBio. 2021 Sep-Oct; 12(5): e01163-21. Published online 2021 Sep 21. doi: 10.1128/mBio.01163-21

PMCID:: PMC8546539

Abstract Article PDF–3.6M

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Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein

Lenka Stejskal, William D. Lees, David S. Moss, Machaela Palor, Richard J. Bingham, Adrian J. Shepherd, Joe Grove

PLoS Comput Biol. 2020 Feb; 16(2): e1007710. Published online 2020 Feb 28. doi: 10.1371/journal.pcbi.1007710

PMCID:: PMC7065822

Abstract Article PDF–3.7M

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Estrogens in Male Physiology

Paul S. Cooke, Manjunatha K. Nanjappa, CheMyong Ko, Gail S. Prins, Rex A. Hess

Physiol Rev. 2017 Jul 1; 97(3): 995–1043. Published online 2017 May 24. doi: 10.1152/physrev.00018.2016

PMCID:: PMC6151497

Abstract Article

Select item 90367299.

2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism

Candice B. Herber, Chaoshen Yuan, Anthony Chang, Jen-Chywan Wang, Isaac Cohen, Dale C. Leitman

Mol Med. 2022; 28: 44. Published online 2022 Apr 25. doi: 10.1186/s10020-022-00470-z

PMCID:: PMC9036729

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A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage response

Apurva T. Prabhakar, Claire D. James, Aya H. Youssef, Reafa A. Hossain, Ronald D. Hill, Molly L. Bristol, Xu Wang, Aanchal Dubey, Elmira Karimi, Iain M. Morgan

mBio. 2024 Jun; 15(6): e00676-24. Published online 2024 May 9. doi: 10.1128/mbio.00676-24

PMCID:: PMC11237546

Abstract Article PDF–2.2M

Select item 600248511.

Pituitary Action of E2 in Prepubertal Grass Carp: Receptor Specificity and Signal Transduction for Luteinizing Hormone and Follicle-Stimulating Hormone Regulation

Xiangfeng Qin, Yaqian Xiao, Cheng Ye, Jingyi Jia, Xiangjiang Liu, Hongwei Liang, Guiwei Zou, Guangfu Hu

Front Endocrinol (Lausanne) 2018; 9: 308. Published online 2018 Jun 8. doi: 10.3389/fendo.2018.00308

PMCID:: PMC6002485

Abstract Article PDF–4.7M

Select item 756371512.

Optimized Hepatitis C Virus (HCV) E2 Glycoproteins and their Immunogenicity in Combination with MVA-HCV

María Q. Marín, Kwinten Sliepen, Juan García-Arriaza, Sylvie M. Koekkoek, Patricia Pérez, Carlos Óscar S. Sorzano, Carmen E. Gómez, Rogier W. Sanders, Mariano Esteban

Vaccines (Basel) 2020 Sep; 8(3): 440. Published online 2020 Aug 5. doi: 10.3390/vaccines8030440

PMCID:: PMC7563715

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Select item 707732113.

Regulation of Transcription Factor E2-2 in Human Plasmacytoid Dendritic Cells by Monocyte-Derived TNFα

Hannah K. Dewald, Harry J. Hurley, Patricia Fitzgerald-Bocarsly

Viruses. 2020 Feb; 12(2): 162. Published online 2020 Jan 31. doi: 10.3390/v12020162

PMCID:: PMC7077321

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A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81

Chun-Chun Chang, Hao-Jen Hsu, Jui-Hung Yen, Shih-Yen Lo, Je-Wen Liou

PLoS One. 2017; 12(5): e0177383. Published online 2017 May 8. doi: 10.1371/journal.pone.0177383

PMCID:: PMC5421814

Abstract Article PDF–15M

Select item 928842315.

Estrogen modulation of the pronociceptive effects of serotonin on female rat trigeminal sensory neurons is timing- and dosage-dependent and requires estrogen receptor alpha

Sukhbir Kaur, Taylor M. Hickman, Angela Lopez-Ramirez, Hanna McDonald, Lauren M. Lockhart, Omar Darwish, Dayna Loyd Averitt

Pain. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Pain. 2022 Aug 1; 163(8): e899–e916. Published online 2022 Feb 2. doi: 10.1097/j.pain.0000000000002604

PMCID:: PMC9288423

Abstract Article PDF–2.6M

Select item 1061751916.

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function

Apurva T. Prabhakar, Claire D. James, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Calvin Yeager, Ronald D. Hill, Aanchal Dubey, Shwu-Yuan Wu, Cheng-Ming Chiang, Iain M. Morgan

J Virol. 2023 Oct; 97(10): e00782-23. Published online 2023 Sep 15. doi: 10.1128/jvi.00782-23

PMCID:: PMC10617519

Abstract Article PDF–2.7M

Select item 774410117.

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

Shivani N Mann, Niran Hadad, Molly Nelson Holte, Alicia R Rothman, Roshini Sathiaseelan, Samim Ali Mondal, Martin-Paul Agbaga, Archana Unnikrishnan, Malayannan Subramaniam, John Hawse, Derek M Huffman, Willard M Freeman, Michael B Stout

eLife. 2020; 9: e59616. Published online 2020 Dec 8. doi: 10.7554/eLife.59616

PMCID:: PMC7744101

Abstract Article PDF–3.3M

Select item 881193018.

Expression, Purification, and Refolding of Chikungunya Virus Full-Length Envelope E2 Protein along with B-Cell and T-Cell Epitope Analyses Using Immuno-Informatics Approaches

Manisha Shukla, Pankaj Chandley, Suman Tapryal, Narendra Kumar, Sulakshana P. Mukherjee, Soma Rohatgi

ACS Omega. 2022 Feb 1; 7(4): 3491–3513. Published online 2022 Jan 14. doi: 10.1021/acsomega.1c05975

PMCID:: PMC8811930

Abstract Article PDF–10M

Select item 659784119.

A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Igf1 (insulin-like growth factor 1)

Sylvia C. Hewitt, Sydney L. Lierz, Marleny Garcia, Katherine J. Hamilton, Artiom Gruzdev, Sara A. Grimm, John P. Lydon, Francesco J. Demayo, Kenneth S. Korach

J Biol Chem. 2019 Jun 21; 294(25): 9746–9759. Published online 2019 May 9. doi: 10.1074/jbc.RA119.008759

PMCID:: PMC6597841

Abstract Article PDF–3.7M

Select item 848624120.

Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus‐neutralizing activity in vaccinated mice

Mihaela‐Olivia Dobrica, André van Eerde, Catalin Tucureanu, Adrian Onu, Lisa Paruch, Iuliana Caras, Ene Vlase, Hege Steen, Sissel Haugslien, Dominic Alonzi, Nicole Zitzmann, Ralph Bock, Jean Dubuisson, Costin‐Ioan Popescu, Crina Stavaru, Jihong Liu Clarke, Norica Branza‐Nichita

Plant Biotechnol J. 2021 Oct; 19(10): 2027–2039. Published online 2021 Jun 3. doi: 10.1111/pbi.13631

PMCID:: PMC8486241

Abstract Article PDF–1.7M

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Fig. 5.

Oxylipin receptors on the platelet and effects on platelet activation. DP: prostaglandin DP receptor; TPα: thromboxane receptor; IP: prostacyclin receptor; PPARα: peroxisome proliferator-activated receptor alpha; PPARβ: peroxisome proliferator-activated receptor beta; PPARγ: peroxisome proliferator-activated receptor gamma; CysLT2R: cysteinyl leukotriene receptor 2; ChemR23: chemerin receptor 23; EP₁: prostaglandin E2 receptor 1; EP₂: prostaglandin E2 receptor 2; EP₃: prostaglandin E2 receptor 3; EP₄: prostaglandin E2 receptor 4; PAR4: protease-activated receptor 4; GPR31: G-protein-coupled receptor 31; PGD₂: prostaglandin D2; PGD₃: prostaglandin D3; TxA₂: thromboxane A2; PGF_2: prostaglandin F2; PGI₂: prostacyclin; 12(S)-HETrE: 12(S)-hydroxy-8,10,14-eicosatrienoic acid; PGE₂: prostaglandin E2; TxA₁: thromboxane A1; PGI₃: prostaglandin I3; 11(S)-HDPA: 11(S)-hydroxy-docosapentaenoic acid; 14(S)-HDPA: 14(S)-hydroxy-docosapentaenoic acid; 15(S)-HETE: 15(S)-hydroxyeicosatetranoic acid; 15(S)-HETrE: 15(S)-hydroxyeicosatrienoic acid; LTC₄: leukotriene C4; Resolvin E₁: 5S,12R,18R-trihydroxyeicosapentaenoic acid; PGE₁: prostaglandin E1; PGE₃: prostaglandin E3; TxA₃ thromboxane A3; 12(S)-HETE: 12(S)-hydroxyeicosatetranoic acid. Created using Biorender.com.

Bioactive lipid regulation of platelet function, hemostasis, and thrombosis

Pharmacol Ther. ;246:108420-108420.
Figure 2.

Signaling pathways associated with ERα. ERα is mainly involved in the E2/ERα signaling pathway, which includes classical and non-classical approaches. In addition, ERα regulates the PI3K/AKT/mTOR, MAPK, WNT/β-catenin and JAK/STAT signaling pathways. ERα, estrogen receptor α; E2, estrogen/estradiol.

Roles of estrogen receptor α in endometrial carcinoma (Review)

Oncol Lett. 2023 Dec;26(6):530.
Fig. 1

E2 induced miR-140 expression in time and concentration dependent. a Influence of E2 (10 nM) on OA-related miRNA expression in primary human articular chondrocytes from female OA patients. b Relative expression of miR-140 in female OA chondrocytes stimulate with different concentration of E2 for 12 hr. c Kinetics of expression of miR-140 expression treated with E2 (10 nM) for 4, 8, 12 and 24 hr in OA chondrocytes from female patients. d E2 induction of miR-140 expression was significantly repressed by estrogen receptor alpha RNAi. Data are represented as mean ± SEM, statistically different from control (^* P < 0.05, ^** P < 0.001). E2 17-β-estradiol, ERα estrogen receptor alpha

E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes

Arthritis Res Ther. 2016;18:105.
Figure 8

The beneficial actions of estrogen receptor α (ERα) activation on atheroma, hypertension, neointimal hyperplasia, and arterial remodeling all rely on nuclear ERα, whereas ERα membrane‐initiated signaling is restricted to the rapid endothelial actions. E2 indicates 17β‐estradiol; E4, estetrol; EDC, estrogen‐dendrimer conjugate; and PaPE, pathway preferential estrogen.

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

J Am Heart Assoc. 2018 Jul 3;7(13):e008950.