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Select item 95033411.

Extracellular vesicle‐bound DNA in urine is indicative of kidney allograft injury

Ivana Sedej, Maja Štalekar, Magda Tušek Žnidarič, Katja Goričar, Nika Kojc, Polona Kogovšek, Vita Dolžan, Miha Arnol, Metka Lenassi

J Extracell Vesicles. 2022 Sep; 11(9): e12268. Published online 2022 Sep 23. doi: 10.1002/jev2.12268

PMCID:: PMC9503341

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Select item 80244192.

FOXP3 mRNA Profile Prognostic of Acute T-cell–mediated Rejection and Human Kidney Allograft Survival

Danny Luan, Darshana M. Dadhania, Ruchuang Ding, Thangamani Muthukumar, Michelle Lubetzky, John R. Lee, Vijay K. Sharma, Phyllis August, Franco B. Mueller, Joseph E. Schwartz, Manikkam Suthanthiran

Transplantation. Author manuscript; available in PMC 2022 Aug 1.

Published in final edited form as: Transplantation. 2021 Aug 1; 105(8): 1825–1839. doi: 10.1097/TP.0000000000003478

PMCID:: PMC8024419

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Select item 84990063.

Urinary Cell mRNA Profiles Predictive of Human Kidney Allograft Status

Michelle L. Lubetzky, Thalia Salinas, Joseph E. Schwartz, Manikkam Suthanthiran

Clin J Am Soc Nephrol. 2021 Oct; 16(10): 1565–1577. Published online 2021 Oct. doi: 10.2215/CJN.14010820

PMCID:: PMC8499006

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Select item 71011354.

Urinary cell transcriptomics and acute rejection in human kidney allografts

Akanksha Verma, Thangamani Muthukumar, Hua Yang, Michelle Lubetzky, Michael F. Cassidy, John R. Lee, Darshana M. Dadhania, Catherine Snopkowski, Divya Shankaranarayanan, Steven P. Salvatore, Vijay K. Sharma, Jenny Z. Xiang, Iwijn De Vlaminck, Surya V. Seshan, Franco B. Mueller, Karsten Suhre, Olivier Elemento, Manikkam Suthanthiran

JCI Insight. 2020 Feb 27; 5(4): e131552. Published online 2020 Feb 27. doi: 10.1172/jci.insight.131552

PMCID:: PMC7101135

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Select item 108379345.

Dysregulated lipid metabolism is associated with kidney allograft fibrosis

Linjie Peng, Chang Wang, Shuangjin Yu, Qihao Li, Guobin Wu, Weijie Lai, Jianliang Min, Guodong Chen

Lipids Health Dis. 2024; 23: 37. Published online 2024 Feb 3. doi: 10.1186/s12944-024-02021-3

PMCID:: PMC10837934

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Select item 57910646.

Dynamic Prognostic Score to Predict Kidney Allograft Survival in Patients with Antibody-Mediated Rejection

Denis Viglietti, Alexandre Loupy, Olivier Aubert, Oriol Bestard, Jean-Paul Duong Van Huyen, Jean-Luc Taupin, Denis Glotz, Christophe Legendre, Xavier Jouven, Michel Delahousse, Nassim Kamar, Carmen Lefaucheur

J Am Soc Nephrol. 2018 Feb; 29(2): 606–619. Published online 2017 Dec 18. doi: 10.1681/ASN.2017070749

PMCID:: PMC5791064

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Select item 79711187.

Early Kidney Allograft Failure after Simultaneous Liver-Kidney Transplantation (SLKT): Evidence for Utilization of the Safety Net

Giuseppe Cullaro, Elizabeth C. Verna, Jean C. Emond, Babak J. Orandi, Sumit Mohan, Jennifer C. Lai

Transplantation. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Transplantation. 2021 Apr 1; 105(4): 816–823. doi: 10.1097/TP.0000000000003310

PMCID:: PMC7971118

Article PDF–421K

Select item 91390858.

Glomerular Diseases of the Kidney Allograft: Toward a Precision Medicine Approach

Francesca Zanoni, Pascale Khairallah, Krzysztof Kiryluk, Ibrahim Batal

Semin Nephrol. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: Semin Nephrol. 2022 Jan; 42(1): 29–43. doi: 10.1016/j.semnephrol.2022.01.005

PMCID:: PMC9139085

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Select item 92310089.

Biological pathways and comparison with biopsy signals and cellular origin of peripheral blood transcriptomic profiles during kidney allograft pathology

Elisabet Van Loon, Baptiste Lamarthée, Henriette de Loor, Amaryllis H. Van Craenenbroeck, Sophie Brouard, Richard Danger, Magali Giral, Jasper Callemeyn, Claire Tinel, Álvaro Cortés Calabuig, Priyanka Koshy, Ben Sprangers, Dirk Kuypers, Wilfried Gwinner, Dany Anglicheau, Pierre Marquet, Maarten Naesens

Kidney Int. 2022 Jul; 102(1): 183–195. doi: 10.1016/j.kint.2022.03.026

PMCID:: PMC9231008

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Select item 1035678510.

Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection

Baptiste Lamarthée, Jasper Callemeyn, Yannick Van Herck, Asier Antoranz, Dany Anglicheau, Patrick Boada, Jan Ulrich Becker, Tim Debyser, Frederik De Smet, Katrien De Vusser, Maëva Eloudzeri, Amelie Franken, Wilfried Gwinner, Priyanka Koshy, Dirk Kuypers, Diether Lambrechts, Pierre Marquet, Virginie Mathias, Marion Rabant, Minnie M. Sarwal, Aleksandar Senev, Tara K. Sigdel, Ben Sprangers, Olivier Thaunat, Claire Tinel, Thomas Van Brussel, Amaryllis Van Craenenbroeck, Elisabet Van Loon, Thibaut Vaulet, Francesca Bosisio, Maarten Naesens

Nat Commun. 2023; 14: 4359. Published online 2023 Jul 19. doi: 10.1038/s41467-023-39859-7

PMCID:: PMC10356785

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Select item 1037702311.

Pathological Approach to Kidney Allograft Infection

Suwasin Udomkarnjananun, Kroonpong Iampenkhae

Biomedicines. 2023 Jul; 11(7): 1902. Published online 2023 Jul 5. doi: 10.3390/biomedicines11071902

PMCID:: PMC10377023

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Select item 1098946512.

Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

Ameet Kumar Jesrani, Syed M Faiq, Rahma Rashid, Tariq Ali Kalwar, Rehan Mohsin, Tahir Aziz, Nida Amin Khan, Muhammed Mubarak

World J Transplant. 2024 Mar 18; 14(1): 89255. Published online 2024 Mar 18. doi: 10.5500/wjt.v14.i1.89255

PMCID:: PMC10989465

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Select item 848794613.

Urinary cell mRNA Profiling of Kidney Allograft Recipients: A Systematic Investigation of a Filtration Based Protocol for the Simplification of Urine Processing

Catherine Snopkowski, Thalia Salinas, Carol Li, Gabriel Stryjniak, Ruchuang Ding, Vijay Sharma, Manikkam Suthanthiran

J Immunol Methods. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: J Immunol Methods. 2021 Nov; 498: 113132. Published online 2021 Aug 28. doi: 10.1016/j.jim.2021.113132

PMCID:: PMC8487946

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Select item 675462314.

Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure

Andrew Bostom, Dominik Steubl, Pranav S. Garimella, Nora Franceschini, Mary B. Roberts, Andreas Pasch, Joachim H. Ix, Katherine R. Tuttle, Anastasia Ivanova, Theresa Shireman, S. Joseph Kim, Reginald Gohh, Daniel E. Weiner, Andrew S. Levey, Chi-yuan Hsu, John W. Kusek, Charles B. Eaton

Am J Nephrol. Author manuscript; available in PMC 2019 Sep 21.

Published in final edited form as: Am J Nephrol. 2018; 47(4): 275–282. Published online 2018 Apr 26. doi: 10.1159/000489095

PMCID:: PMC6754623

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Select item 854990815.

Up-Regulation of CD163 Expression in Subpopulations of Blood Monocytes After Kidney Allograft Transplantation

Lenka ČURNOVÁ, Kristýna MEZEROVÁ, Veronika ŠVACHOVÁ, Martina FIALOVÁ, Marek NOVOTNÝ, Eva ČEČRDLOVÁ, Ondřej VIKLICKÝ, Ilja STŘÍŽ

Physiol Res. 2020 Oct; 69(5): 885–896. Published online 2020 Sep 9. doi: 10.33549/physiolres.934531

PMCID:: PMC8549908

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Select item 999224616.

Urine as liquid gold: the transcriptional landscape of acute rejection defined by urinary cell mRNA profiling of kidney allograft recipients

Manikkam Suthanthiran

Curr Opin Organ Transplant. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Curr Opin Organ Transplant. 2023 Apr 1; 28(2): 117–125. Published online 2023 Feb 9. doi: 10.1097/MOT.0000000000001051

PMCID:: PMC9992246

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Select item 839988817.

Kidney Allograft Function Is a Confounder of Urine Metabolite Profiles in Kidney Allograft Recipients

Karsten Suhre, Darshana M. Dadhania, John Richard Lee, Thangamani Muthukumar, Qiuying Chen, Steven S. Gross, Manikkam Suthanthiran

Metabolites. 2021 Aug; 11(8): 533. Published online 2021 Aug 11. doi: 10.3390/metabo11080533

PMCID:: PMC8399888

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Select item 804932918.

Deep sequencing of DNA from urine of kidney allograft recipients to estimate donor/recipient-specific DNA fractions

Aziz Belkadi, Gaurav Thareja, Darshana Dadhania, John R. Lee, Thangamani Muthukumar, Catherine Snopkowski, Carol Li, Anna Halama, Sara Abdelkader, Silvana Abdulla, Yasmin Mahmoud, Joel Malek, Manikkam Suthanthiran, Karsten Suhre

PLoS One. 2021; 16(4): e0249930. Published online 2021 Apr 15. doi: 10.1371/journal.pone.0249930

PMCID:: PMC8049329

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Select item 756968619.

Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection

Silvia Pineda, Swastika Sur, Tara Sigdel, Mark Nguyen, Elena Crespo, Alba Torija, Maria Meneghini, Montse Gomà, Marina Sirota, Oriol Bestard, Minnie M. Sarwal

Kidney Int Rep. 2020 Oct; 5(10): 1706–1721. Published online 2020 Jul 26. doi: 10.1016/j.ekir.2020.07.023

PMCID:: PMC7569686

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Select item 469657420.

IgG Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated Injury

Carmen Lefaucheur, Denis Viglietti, Carol Bentlejewski, Jean-Paul Duong van Huyen, Dewi Vernerey, Olivier Aubert, Jérôme Verine, Xavier Jouven, Christophe Legendre, Denis Glotz, Alexandre Loupy, Adriana Zeevi

J Am Soc Nephrol. 2016 Jan; 27(1): 293–304. Published online 2015 Aug 20. doi: 10.1681/ASN.2014111120

PMCID:: PMC4696574

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PMC Images search for "kidney allograft"

FIGURE 3

(A) Kaplan–Meier plot of patient survival after kidney allograft loss. Median patient survival after kidney allograft loss was 58 months. ESP-KTRs with kidney allograft loss <12 months post-transplantation showed inferior patient survival compared with ESP-KTRs with kidney allograft loss >12 months post-transplantation. (B) Kaplan–Meier plot of patient survival after kidney allograft loss between male ESP-KTRs and female ESP-KTRs. No differences are shown for patient survival after kidney allograft loss between male ESP-KTRs and female ESP-KTRs.

Two decades of the Eurotransplant Senior Program: the gender gap in mortality impacts patient survival after kidney transplantation

Clin Kidney J. 2020 Dec;13(6):1091-1100.
FIGURE 1:

Patient and kidney allograft survival after belatacept treatment. (A) Kaplan–Meier estimate of patient survival was similar in HIV-positive kidney allograft recipients converted to belatacept compared with the control group of HIV-positive kidney allograft recipients treated with CNI (P = 0.38). (B) Kaplan–Meier estimate of kidney allograft survival, in HIV-positive kidney allograft recipients converted to belatacept compared with the control group of HIV-positive kidney allograft recipients treated with CNI (P = 0.36). (C) eGFR and proteinuria evolution after belatacept conversion. eGFR increased significantly 3 and 12 months after belatacept conversion (P = 0.01 and P = 0.009, respectively). Proteinuria tended to decrease at 3 months (P = 0.08), which is no longer observed at 12 months (P = 0.22).

Belatacept-based immunosuppressive regimen in HIV-positive kidney transplant recipients

Clin Kidney J. 2021 Aug;14(8):1908-1914.
FIGURE 8

The kidney allograft was repaired to make it watertight.

Renal Autotransplantation and Extracorporeal Nephron-Sparing Surgery for De Novo Renal Cell Carcinoma in a Kidney Allograft

Transplant Direct. 2017 Aug;3(8):e122.
Fig. 1Conceptualization of the kidney allograft as an in-vivo flow cytometer

Interstitial inflammation and tubilitis are the histological hallmarks of ACR in the kidney allograft (left panel). Since ACR involves infiltration of T lymphocytes and additional cells into the tubular space, the kidney allograft is conceptualized to function as an in vivo flow cytometer (middle panel) facilitating the entry of graft destructive/protective T lymphocytes and other immune cells and graft parenchymal cells into the urinary space. In this formulation, urinary cell mRNA profiling reflects intragraft events deterministic of allograft status.

Urinary Cell mRNA Profiles Predictive of Human Kidney Allograft Status

Immunol Rev. ;258(1):218-240.