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Select item 42305081.

Alpha-synuclein and tau: teammates in neurodegeneration?

Simon Moussaud, Daryl R Jones, Elisabeth L Moussaud-Lamodière, Marion Delenclos, Owen A Ross, Pamela J McLean

Mol Neurodegener. 2014; 9: 43. Published online 2014 Oct 29. doi: 10.1186/1750-1326-9-43

PMCID:: PMC4230508

Abstract Article PDF–1.6M

Select item 103303672.

Microglia-specific knock-out of NF-κB/IKK2 increases accumulation of misfolded α-synuclein through inhibition of p62/SQSTM-1-dependent autophagy in the rotenone model of Parkinson’s disease

Savannah M. Rocha, Kelly S. Kirkley, Debotri Chatterjee, Tawfik A. Aboellail, Richard J. Smeyne, Ronald B. Tjalkens

Glia. Author manuscript; available in PMC 2024 Sep 1.

Published in final edited form as: Glia. 2023 Sep; 71(9): 2154–2179. Published online 2023 May 18. doi: 10.1002/glia.24385

PMCID:: PMC10330367

Abstract Article PDF–5.4M

Select item 89258633.

Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease

Serge Moudio, Fredrik Rodin, Nazira Jamal Albargothy, Urban Karlsson, Juan F. Reyes, Martin Hallbeck

Front Neurol. 2022; 13: 826102. Published online 2022 Feb 16. doi: 10.3389/fneur.2022.826102

PMCID:: PMC8925863

Abstract Article PDF–4.3M

Select item 65278554.

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease

Takuya Uehara, Chi-Jing Choong, Masayuki Nakamori, Hideki Hayakawa, Kumiko Nishiyama, Yuuya Kasahara, Kousuke Baba, Tetsuya Nagata, Takanori Yokota, Hiroshi Tsuda, Satoshi Obika, Hideki Mochizuki

Sci Rep. 2019; 9: 7567. Published online 2019 May 21. doi: 10.1038/s41598-019-43772-9

PMCID:: PMC6527855

Abstract Article PDF–3.0M

Select item 101192235.

Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism

Chi-Jing Choong, César Aguirre, Keita Kakuda, Goichi Beck, Hiroki Nakanishi, Yasuyoshi Kimura, Shuichi Shimma, Kei Nabekura, Makoto Hideshima, Junko Doi, Keiichi Yamaguchi, Kichitaro Nakajima, Tomoya Wadayama, Hideki Hayakawa, Kousuke Baba, Kotaro Ogawa, Toshihide Takeuchi, Shaymaa Mohamed Mohamed Badawy, Shigeo Murayama, Seiichi Nagano, Yuji Goto, Yohei Miyanoiri, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka

Acta Neuropathol. 2023; 145(5): 573–595. Published online 2023 Mar 20. doi: 10.1007/s00401-023-02555-3

PMCID:: PMC10119223

Abstract Article PDF–9.7M

Select item 99492676.

Distinct biological activity of Lewy body α-Synuclein strain in mice

Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin Luk, John Trojanowski, Virginia Lee

Version 1. Res Sq. Preprint. 2023 Feb 16. doi: 10.21203/rs.3.rs-2579805/v1

Published in:: Nat Commun. 2023; 14: 6892.

PMCID:: PMC9949267

Abstract Article PDF–11M

Select item 99322067.

Nicotine alleviates MPTP-induced nigrostriatal damage through modulation of JNK and ERK signaling pathways in the mice model of Parkinson’s disease

Sisi Ruan, Jiqing Xie, Linhai Wang, Lulu Guo, Yan Li, Wu Fan, Rongzhan Ji, Zhenlin Gong, Yan Xu, Jian Mao, Jianping Xie

Front Pharmacol. 2023; 14: 1088957. Published online 2023 Feb 2. doi: 10.3389/fphar.2023.1088957

PMCID:: PMC9932206

Abstract Article PDF–3.8M

Select item 109425508.

Soluble and insoluble lysates from the human A53T mutant α-synuclein transgenic mouse model induces α-synucleinopathy independent of injection site

Michael Lee, Justin Barnes, Scott Vermilyea, Joyce Meints, Hector Martinez

Version 1. Res Sq. Preprint. 2024 Mar 5. doi: 10.21203/rs.3.rs-3982325/v1

PMCID:: PMC10942550

Abstract Article PDF–3.0M

Select item 75340999.

Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson’s Disease: The Implications of Sample Thickness on Results

Ningshan Wang, Jennifer Garcia, Roy Freeman, Christopher H. Gibbons

J Histochem Cytochem. 2020 Oct; 68(10): 669–678. Published online 2020 Sep 14. doi: 10.1369/0022155420960250

PMCID:: PMC7534099

Abstract Article PDF–723K

Select item 587416410.

Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease

Aron S. Buchman, Sukriti Nag, Sue E. Leurgans, Jared Miller, Veronique G. J. M. VanderHorst, David A. Bennett, Julie A. Schneider

Brain Pathol. 2018 Jul; 28(4): 560–568. Published online 2017 Oct 27. doi: 10.1111/bpa.12560

PMCID:: PMC5874164

Abstract Article PDF–617K

Select item 588491411.

Prion-Like Seeding of Misfolded α-Synuclein in the Brains of Dementia with Lewy Body Patients in RT-QUIC

Kazunori Sano, Ryuichiro Atarashi, Katsuya Satoh, Daisuke Ishibashi, Takehiro Nakagaki, Yasushi Iwasaki, Mari Yoshida, Shigeo Murayama, Kenichi Mishima, Noriyuki Nishida

Mol Neurobiol. 2018; 55(5): 3916–3930. Published online 2017 May 26. doi: 10.1007/s12035-017-0624-1

PMCID:: PMC5884914

Abstract Article PDF–1.9M

Select item 594214212.

Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum

Yanan Luan, Xiangpeng Ren, Wu Zheng, Zhenhai Zeng, Yingzi Guo, Zhidong Hou, Wei Guo, Xingjun Chen, Fei Li, Jiang-Fan Chen

Front Neurosci. 2018; 12: 301. Published online 2018 May 2. doi: 10.3389/fnins.2018.00301

PMCID:: PMC5942142

Abstract Article PDF–5.5M

Select item 1081815713.

Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons

Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takata

Regen Ther. 2024 Mar; 25: 229–237. Published online 2024 Jan 6. doi: 10.1016/j.reth.2023.12.019

PMCID:: PMC10818157

Abstract Article PDF–3.7M

Select item 918711514.

Alpha-synuclein and tau are abundantly expressed in the ENS of the human appendix and monkey cecum

Alexandra D. Zinnen, Jonathan Vichich, Jeanette M. Metzger, Julia C. Gambardella, Viktoriya Bondarenko, Heather A. Simmons, Marina E. Emborg

PLoS One. 2022; 17(6): e0269190. Published online 2022 Jun 10. doi: 10.1371/journal.pone.0269190

PMCID:: PMC9187115

Abstract Article PDF–4.8M

Select item 903752215.

Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model

Ruolin Li, Yongquan Lu, Qidi Zhang, Weijin Liu, Runing Yang, Jie Jiao, Jia Liu, Ge Gao, Hui Yang

Autophagy. 2022; 18(3): 559–575. Published online 2021 Aug 25. doi: 10.1080/15548627.2021.1937897

PMCID:: PMC9037522

Abstract Article PDF–5.6M

Select item 614011616.

Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology

Kyota Fujita, Hidenori Homma, Kanoh Kondo, Masashi Ikuno, Hodaka Yamakado, Kazuhiko Tagawa, Shigeo Murayama, Ryosuke Takahashi, Hitoshi Okazawa

eNeuro. 2018 Jul-Aug; 5(4): ENEURO.0217-18.2018. Prepublished online 2018 Aug 16. Published online 2018 Sep 4. doi: 10.1523/ENEURO.0217-18.2018

PMCID:: PMC6140116

Abstract Article PDF–6.2M

Select item 935714817.

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s Disease

Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou, Manoj Kumar, Saurav Brahmachari, Aanishaa Jhaldiyal, Jared T. Hinkle, Fatih Akkentli, Xiaobo Mao, Enquan Xu, Senthilkumar S. Karuppagounder, Eric T. Hsu, Sung Ung Kang, Olga Pletnikova, Juan Troncoso, Valina L. Dawson, Ted M. Dawson

Neuron. Author manuscript; available in PMC 2023 Aug 3.

Published in final edited form as: Neuron. 2022 Aug 3; 110(15): 2422–2437.e9. Published online 2022 Jun 1. doi: 10.1016/j.neuron.2022.05.009

PMCID:: PMC9357148

Abstract Article PDF–4.2M

Select item 921878718.

Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1

Masayuki Nakamori, Hiroshi Shimizu, Kotaro Ogawa, Yuhei Hasuike, Takashi Nakajima, Hidetoshi Sakurai, Toshiyuki Araki, Yukinori Okada, Akiyoshi Kakita, Hideki Mochizuki

Brain Commun. 2022; 4(3): fcac154. Published online 2022 Jun 10. doi: 10.1093/braincomms/fcac154

PMCID:: PMC9218787

Abstract Article PDF–1.8M

Select item 562840719.

Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease

Yumiko V. Taguchi, Jun Liu, Jiapeng Ruan, Joshua Pacheco, Xiaokui Zhang, Justin Abbasi, Joan Keutzer, Pramod K. Mistry, Sreeganga S. Chandra

J Neurosci. 2017 Oct 4; 37(40): 9617–9631. doi: 10.1523/JNEUROSCI.1525-17.2017

PMCID:: PMC5628407

Abstract Article PDF–5.2M

Select item 1124201820.

Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration

Tingfu Du, Guoxiang Li, Qinglan Zong, Haiyu Luo, Yue Pan, Kaili Ma

Immun Ageing. 2024; 21: 47. Published online 2024 Jul 12. doi: 10.1186/s12979-024-00429-0

PMCID:: PMC11242018

Abstract Article PDF–14M

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