Q9HC29[UniProt Accession] - PubChem BioAssay - NCBI

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Select item 19507591.

Antagonist activity at NOD2 in human HEK-Blue hNOD2 cells assessed as inhibition of MDP-induced NOD2 activation

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Tested

AID:: 1950759

Summary PubMed Citation Related BioAssays by Target

Select item 18711282.

Synergistic agonist activity at NOD2 in human PBMC assessed as induction of TNF-alpha production at 1 uM incubated for 18 hrs in presence of LPS

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Active, 1 Tested

AID:: 1871128

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18711273.

Synergistic agonist activity at NOD2 in human PBMC assessed as induction of IL-6 production at 1 uM incubated for 18 hrs in presence of LPS

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Active, 1 Tested

AID:: 1871127

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18711264.

Synergistic agonist activity at NOD2 in human PBMC assessed as induction of IL-1beta production at 1 uM incubated for 18 hrs in presence of LPS

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Active, 1 Tested

AID:: 1871126

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18711255.

Synergistic agonist activity at NOD2 in human PBMC assessed as induction of IL-8 production at 1 uM incubated for 18 hrs in presence of IFN-gamma

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Tested

AID:: 1871125

Summary PubMed Citation Related BioAssays by Target

Select item 18711246.

Synergistic agonist activity at NOD2 in human PBMC assessed as induction of TNFalpha production at 1 uM incubated for 18 hrs in presence of IFN-gamma

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Active, 1 Tested

AID:: 1871124

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18711237.

Synergistic agonist activity at NOD2 in human PBMC assessed as induction of IL-6 production at 1 uM incubated for 18 hrs in presence of IFN-gamma

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Active, 1 Tested

AID:: 1871123

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18711228.

Synergistic agonist activity at NOD2 in human PBMC assessed as induction of IL-1beta production at 1 uM incubated for 18 hrs in presence of IFN-gamma

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Active, 1 Tested

AID:: 1871122

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18711219.

Agonist activity at NOD2 in human PBMC assessed as induction of TNFalpha production at 1 uM incubated for 18 hrs pretreated with NOD2 antagonist

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Tested

AID:: 1871121

Summary PubMed Citation Related BioAssays by Target

Select item 187112010.

Agonist activity at NOD2 in human PBMC assessed as induction of IL-6 production at 1 uM incubated for 18 hrs pretreated with NOD2 antagonist

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Tested

AID:: 1871120

Summary PubMed Citation Related BioAssays by Target

Select item 187111911.

Agonist activity at NOD2 in human PBMC assessed as induction of IL-1beta production at 1 uM incubated for 18 hrs pretreated with NOD2 antagonist

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Tested

AID:: 1871119

Summary PubMed Citation Related BioAssays by Target

Select item 187111812.

Agonist activity at NOD2 in human PBMC assessed as induction of IL-8 production at 1 uM incubated for 18 hrs pretreated with NOD2 antagonist

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Tested

AID:: 1871118

Summary PubMed Citation Related BioAssays by Target

Select item 187111713.

Agonist activity at NOD2 in human PBMC assessed as induction of TNFalpha production at 1 uM incubated for 18 hrs

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:3 Active, 3 Tested

AID:: 1871117

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187111614.

Agonist activity at NOD2 in human PBMC assessed as induction of IL-8 production at 1 uM incubated for 18 hrs

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:3 Active, 3 Tested

AID:: 1871116

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187111515.

Agonist activity at NOD2 in human PBMC assessed as induction of IL-6 production at 1 uM incubated for 18 hrs

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:3 Active, 3 Tested

AID:: 1871115

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187111416.

Agonist activity at NOD2 in human PBMC assessed as induction of IL-1beta production at 1 uM incubated for 18 hrs

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:3 Active, 3 Tested

AID:: 1871114

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187111117.

Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells in presence of NOD2 antagonist by colorimetry based SEAP assay

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:27 Tested

AID:: 1871111

Summary PubMed Citation Related BioAssays by Target

Select item 187110918.

Agonist activity at human human NOD2 expressed in HEK-Blue NOD2 reporter cells by colorimetry based SEAP assay

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:24 Active, 17 Activity ≤ 1 µM, 27 Tested

AID:: 1871109

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186894719.

Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in SEAP activity at 20 ug incubated for 24 hrs by Quanti-blue assay

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:6 Active, 6 Tested

AID:: 1868947

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 184890420.

Agonist activity at NOD2 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB activation at 10 uM incubated for 18 hrs by SEAP-based spectrophotometry analysis

Source:: ChEMBL

Protein Target:: Nucleotide-binding oligomerization domain-containing protein 2

Assay data:1 Tested

AID:: 1848904

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (7)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (62)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (19)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (26)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (6)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (111)
BioAssays extracted from the literature
NIH MLP (6)
BioAssays deposited by the NIH Molecular Libraries Program

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