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Agonist activity at TLR1/TLR2 in wild type C57BL/6J mouse macrophages assessed as stimulation of TNF alpha release measured for 4 hrs by ELISA based assay relative to diprovocim-1
Assay data:78 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at TLR1/TLR2 in wild type C57BL/6J mouse macrophages assessed as stimulation of TNF alpha release measured for 4 hrs by ELISA based assay
Assay data:90 Active, 8 Activity ≤ 1 nM, 90 Activity ≤ 1 µM, 94 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Pam3CSK4-induced TLR1/TLR2 activation in mouse RAW 264.7 cells assessed as reduction in NO production incubated for 24 hrs by 2,3-diaminonaphthalene reagent based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at TLR1/2 in mouse RAW264.7 cells assessed as inhibition of Pam3CSK4-induced receptor activation by measuring NO production after 24 hrs
Assay data:20 Active, 2 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Pam3CSK4-induced TLR1/TLR2 activation in mouse RAW 264.7 cells assessed as reduction in NO production at 3 uM incubated for 24 hrs by 2,3-diaminonaphthalene reagent based assay relative to control
Assay data:1 Tested
Antagonist activity at TLR2/TLR1 in mouse BMDM assessed as inhibition of Rhodamine-labeled Pam3CSK4-stimulated receptor internalization at 1 uM preincubated for 1 hr followed by Rhodamine-Pam3CSK4 stimulation for 20 mins by FACS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at TLR2/TLR1 in mouse BMDM assessed as inhibition of Rhodamine-labeled Pam3CSK4-stimulated receptor internalization at 50 uM preincubated for 1 hr followed by Rhodamine-Pam3CSK4 stimulation for 20 mins by DAPI staining based phase contrast fluorescence microscopic method
Assay data:2 Active, 2 Tested
Inhibition of TLR1/TLR2 in Pam3CSK4-stimulated mouse RAW264.7 cells at 0.6 uM after 24 hrs
Agonist activity at TLR2/1 in mouse BV2 cells assessed as induction of IL-6 production at 2 uM incubated for 24 hrs in presence of TLR2/1 inhibitor CU-CPT22 by ELISA
Antagonist activity at TLR2/1 in mouse RAW264.7 cells assessed as reduction in PAM3CSK4-induced TNFalpha secretion at 20 to 80 uM after 24 hrs by ELISA
Antagonist activity at TLR2/TLR1 in mouse BMDM assessed as Rhodamine-labeled Pam3CSK4-stimulated receptor internalization at 50 uM preincubated for 1 hr followed by Rhodamine-Pam3CSK4 stimulation for 20 mins by FACS analysis relative to control
Assay data:2 Tested
Antagonist activity at TLR2/TLR1 in mouse BMDM assessed as inhibition of Pam3CSK4-stimulated TNFalpha production by measuring TNFalpha level at 25 uM preincubated for 1 hr followed by Pam3CSK4 stimulation for 11 hrs by ELISA relative to control
Inhibition TLR1-mediated NO production in mouse RAW264.7 cells at 300 uM
Antagonist activity at TLR1/2 in mouse RAW264.7 cells assessed as inhibition of Pam3CSK4-induced receptor activation by measuring NO production at 3 uM after 24 hrs
Assay data:10 Tested
SummaryRelated BioAssays by Target
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