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Agonist activity at TLR7/8 in mouse RAW-blue cells assessed as immune activation by measuring induction of NFkappaB activation at 500 nM measured after 24 hrs by quanti-blue SEAP reporter gene-based assay
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at TLR7/TLR8 in mouse BMDM assessed as inhibition of R848-stimulated TNFalpha production at 25 uM preincubated for 1 hr followed by R848 stimulation for 11 hrs by ELISA
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TLR7/TLR8 in R848-stimulated mouse RAW264.7 cells at 0.6 uM after 24 hrs
Assay data:1 Tested
Agonist activity at mouse TLR8 expressed in HEK293 cells after 6 hrs by NFkappaB-luciferase reporter gene assay
Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of TNF-alpha production at 30 uM after 3 days by flow cytometric analysis
Assay data:15 Tested
Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-1beta production at 30 uM after 3 days by flow cytometric analysis
Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-12p40 production at 30 uM after 3 days by flow cytometric analysis
Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-10 production at 30 uM after 3 days by flow cytometric analysis
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