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Inhibition of TLR7 expression in R848-stimulated mouse BMDC cells at 1 to 4 uM treated for 2 hrs followed by R848 stimulation for 12 hrs by western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at gardiquimod stimulated TRL7 in mouse whole blood assessed as inhibition of IL-6 production by ELISA analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at mouse TLR7 expressed in human whole blood assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins followed by stimulation and measured after 20 hrs by AlphaLISA method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at mouse TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins followed by stimulation and measured after 20 hrs by AlphaLISA method
Agonist activity at TLR7/8 in mouse RAW-blue cells assessed as immune activation by measuring induction of NFkappaB activation at 500 nM measured after 24 hrs by quanti-blue SEAP reporter gene-based assay
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 production
Assay data:12 Active, 10 Activity ≤ 1 µM, 12 Tested
Antagonist activity at TLR7 in mouse P4H1 cells assessed as inhibition of imiquimod-induced IL6 production
Invivo antagonist activity at TLR7 in po dosed C57BL/6 mouse assessed as reduction of gardiquimod-induced IL-6 production pretreated for 30 mins followed by gardiquimod-stimulation and measured after 120 mins by ELISA
Antagonist activity at TLR7 in mouse whole blood cells assessed as inhibition of gardiquimod induced IL-6 production by ELISA
Antagonist activity at TLR7 in mouse whole blood assessed as inhibition of DOTAP-ssRNA40 induced IFNalpha production preincubated for 30 mins followed by ssRNA40 addition measured after 20 hrs by ELISA
Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion preincubated with actin polymerization inhibitor cytochalasin D followed by incubation with compound for 6 hrs by ELISA
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion incubated for 6 hrs in absence of actin polymerization inhibitor cytochalasin D by ELISA
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Agonist activity at TLR7 in mouse BMDC cells assessed as immunostimulatory activity by measuring increase in IL6 secretion incubated for 18 hrs by ELISA
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion incubated for 18 hrs by ELISA
Agonist activity at mouse TLR7 expressed in HEK293 cells after 6 hrs by NFkappaB-luciferase reporter gene assay
Agonist activity at TLR7 in Balb/c mouse splenocytes assessed as induction of IL-6 secretion in supernatant after 18 hrs
Assay data:12 Active, 5 Activity ≤ 1 µM, 13 Tested
Agonist activity at mouse TLR7
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
In vivo antagonist activity at TLR7 in po dosed 129Sv mouse assessed as inhibition of DOTAP-ssRNAR0006-induced IFNalpha release pretreated for 1 hr followed by DOTAP-ssRNAR0006 addition and measure after 2 hrs by ELISA
Antagonist activity at TLR7/TLR8 in mouse BMDM assessed as inhibition of R848-stimulated TNFalpha production at 25 uM preincubated for 1 hr followed by R848 stimulation for 11 hrs by ELISA
Assay data:2 Tested
Antagonist activity at TLR7 in mouse RAW264.7 cells assessed as inhibition of R848-induced receptor activation by measuring NO production at 0.5 uM after 24 hrs
SummaryRelated BioAssays by Target
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