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Toxicity in wild-type Zebrafish embryos measured after 72 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Toxicity in wild-type Zebrafish embryos measured after 48 hrs
Competitive inhibition of N-terminal His-SUMO tagged zebra fish recombinant HDAC6 catalytic domain 2 transfected with pET28b(+) vector in Escherichia coli BL21 (DE3) RILP cells incubated for 10 mins followed by addition of FITC-M344 measured af ter 10 mins by fluorescence polarization assay
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
Antiangiogenic activity in transgenic zebrafish embryo assessed as inhibition of angiogenic vessel growth incubated for 24 hrs by FITC staining based analysis
Inhibition of zebra fish HDAC10 using Ac-spermidine-AMC as substrate incubated for 25 mins and measured by fluorescence assay
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Toxicity in wild type zebrafish embryo in E3 medium treated for 2 days observed on 24 hrs of post fertilization by microscopy
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Toxicity in 3hpf zebrafish AB embryo assessed as NOAEL measured 96 hpf
Assay data:1 Active, 1 Activity ≤ 1 µM, 11 Tested
Inhibition of zebrafish HDAC10 (2 to 675 residues) expressed in Escherichia coli BL21(DE3) cells using N-acetylputrescine as substrate preincubated for 10 mins followed by substrate and measured after 45 to 60 mins by liquid chromatography-mass spectrometry
Agonist activity at zebrafish GPR34 type b expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Agonist activity at zebrafish GPR34 type a expressed in HEK293 cells co-transfected with AP-TGFalpha/Galphaq/i1 assessed as induction of ectodomain shedding of membrane bound AP-TGFalpha after 1 hr by p-NPP substrate based microplate reader analysis
Anticonvulsant activity in AB zebra fish larvae assessed as reduction in PTZ-induced convulsant behavior by measuring lowest observed effect concentration pretreated for 6 hrs followed by PTZ-stimulation and measured every 5 mins for 1 hr
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Toxicity in AB zebra fish larvae assessed as maximum tolerated concentration after 6 hrs
Inhibition of N-terminal 6 His-SUMO tagged Zebrafish HDAC6 CD2 domain expressed in Escherichia coli BL21(DE3) RILP pretreated for 10 mins before FITC-M344 addition and measured after 10 mins by fluorescence polarization competition assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Agonist activity at Zebra fish V2R expressed in African green monkey COS-1 cells assessed as increase in intracellular calcium response by FLIPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at Zebra fish V1a1R expressed in African green monkey COS-1 cells assessed as increase in intracellular calcium response by FLIPR assay
Antagonist activity at zebrafish AhR2 expressed in COS7 cells transfected with ARNT-1c, Cyp1a-firefly luciferase and pRL-TK Renilla luciferase plasmids assessed as inhibition of AhR transcriptional activity administered at 5 hrs post-transfection treated with TCDD at 1 hr post-compound treatment and measured for 10 sec after a 3 sec delay at 18 hrs post-TCDD challenge by dual luciferase reporter gene assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Anti-angiogenic activity in zebrafish-guided angiogenesis model assessed as reduction in inter-segmental blood vessels measured at 72 hpf by fluorescence microscopy
Assay data:8 Active, 1 Activity ≤ 1 µM, 24 Tested
Agonist activity at zebrafish VDR LBD (156 to 453 residues) expressed in HEK293 EBNA cells harboring human CYP24-Tk-Luc plasmid assessed as induction of CYP24a1 gene after 18 hrs by dual-luciferase transcriptional reporter gene assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Protection against neomycin-induced hair cell death in AB zebra fish larvae assessed as increase in hair cell survival preincubated for 1 hr followed by neomycin challenge for 1 hr by DASPEI staining-based epifluorescence dissecting microscopic method
Assay data:65 Active, 28 Activity ≤ 1 µM, 99 Tested
Displacement of [3H]DPN from zebrafish delta 1b opioid receptor expressed in HEK293 cell membranes after 4 hrs by scintillation counting method
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