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Toxicity in wild-type Zebrafish embryos assessed as lethal effect
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Toxicity in wild-type Zebrafish embryos measured after 72 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Toxicity in wild-type Zebrafish embryos measured after 48 hrs
Anti-angiogenesis activity in zebrafish embryo assessed as blockage of intersegmental vessels formation at 0.2 uM measured after 24 hrs by Flourescence assay
Anti-angiogenesis activity in zebrafish embryo assessed as blockage of intersegmental vessels formation at 0.1 uM measured after 24 hrs by Flourescence assay
Anti-angiogenesis activity in zebrafish embryo assessed as blockage of intersegmental vessels formation at 0.05 uM measured after 24 hrs by Flourescence assay
Anti-melanogenic activity in mpx:GFP transgenic zebrafish 24 hrs post fertilization embryo neutrophils assessed as decrease in pigmentation at 2 to 2.5 mg/ml
Anti-melanogenic activity in mpx:GFP transgenic zebrafish 24 hrs post fertilization embryo neutrophils assessed as decrease in pigmentation at 25 ug/ml
Assay data:2 Active, 2 Tested
Anti-melanogenic activity in wild type zebrafish embryo melanocytes assessed as decrease in pigmentation at <10 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization
Anti-melanogenic activity in wild type zebrafish embryo melanocytes assessed as decrease in pigmentation at 2.5 mg/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization
Assay data:3 Active, 3 Tested
Anti-melanogenic activity in wild type zebrafish embryo melanocytes assessed as decrease in pigmentation at 25 ug/ml treated for 72 hrs post fertilization starting from 6 to 24 hrs post fertilization
Functional Calcium Imaging Assay from Article 10.1074/jbc.M114.573162: "ORA1, a zebrafish olfactory receptor ancestral to all mammalian V1R genes, recognizes 4-hydroxyphenylacetic acid, a putative reproductive pheromone."
Assay data:1 Active, 11 Tested
Induction of apoptosis in zebrafish embryo assessed as increase intracellular ROS level at 0.01 to 1 uM measured by DCFH-DA dye based flow cytometric analysis
Competitive inhibition of N-terminal His-SUMO tagged zebra fish recombinant HDAC6 catalytic domain 2 transfected with pET28b(+) vector in Escherichia coli BL21 (DE3) RILP cells incubated for 10 mins followed by addition of FITC-M344 measured af ter 10 mins by fluorescence polarization assay
Assay data:9 Active, 8 Activity ≤ 1 µM, 9 Tested
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in brain at 0.7 uM measured after 14 days by microscopy
Assay data:1 Active, 2 Tested
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in brain at 8.9 uM measured after 14 days by microscopy
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in muscle at 0.5 uM measured after 14 days by microscopy
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in heart at 0.5 uM measured after 14 days by microscopy
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in yolk sac at 0.5 uM measured after 14 days by microscopy
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in brain at 0.5 uM measured after 14 days by microscopy
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