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Therapeutic index, ratio of LD50 for toxicity in ip dosed rodent to ED50 for analgesic activity in ip dosed rodent
Assay data:1 Tested
SummaryPubMed Citation
Toxicity in ip dosed rodent
Analgesic activity in ip dosed formalin-induced pain rodent model
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents
Assay data:944 Tested
Lethal dose against rodents; Range = 1200-10e4 nmol/kg
Lethal dose against rodents; Range = 12-120 nmol/kg
Lethal dose against rodents; Range = 1.38e7 nmol/kg
Lethal dose against rodents; Range = 1.37e5 nmol/kg
Lethal dose against rodents; nd is not determined
Assay data:7 Tested
Lethal dose against rodents; Range = 7-67 nmol/kg
Assay data:2 Tested
Lethal dose against rodents; Range = 1200-10e4
Lethal dose against rodents
Iron clearing efficiency in bile-duct-cannulated rodents following a subcutaneous dosage of 450 umol/kg
Iron clearing efficiency in urine of rodents following a subcutaneous dosage of 450 umol/kg
Iron clearing efficiency in bile of rodents following a subcutaneous dosage of 450 umol/kg
Therapeutic index calculated as the ratio of LD50 in mice to ED 150 in rat when administered intravenously
Assay data:66 Tested
Toxicity after intraperitoneal administration in rats and mice
Assay data:3 Tested
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