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Cmax in pig-tail monkey plasma assessed as 6-Diazo-5-oxo-L-norleucine levels at 3.6 mg/kg, iv by LC-MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Cmax in pig-tail monkey plasma at 1.6 mg/kg, iv by LC-MS analysis
Assay data:1 Tested
SummaryPubMed Citation
Prodrug activation in pig-tail monkey CSF assessed as 6-Diazo-5-oxo-L-norleucine levels at 3.6 mg/kg, iv measured at 30 mins post dose by LC-MS analysis
Drug uptake in pig-tail monkey CSF at 1.6 mg/kg, iv measured at 30 mins post dose by LC-MS analysis
AUC (0 to t) in pig-tail monkey plasma assessed as 6-Diazo-5-oxo-L-norleucine levels at 3.6 mg/kg, iv measured at 0.25 to 6 hrs post dose by LC-MS analysis
AUC (0 to t) in pig-tail monkey plasma at 1.6 mg/kg, iv measured at 0.25 to 6 hrs post dose by LC-MS analysis
Tmax in pig-tail monkey plasma assessed as 6-Diazo-5-oxo-L-norleucine levels at 3.6 mg/kg, iv by LC-MS analysis
Tmax in pig-tail monkey plasma at 1.6 mg/kg, iv by LC-MS analysis
In vitro inhibition of [3H]-Spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes (using L-tartrate salt of authentic raclopride)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes
Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested
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