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Protein binding in marmoset plasma
Assay data:1 Tested
Summary
Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 3 mg/kg, sc measured after 15 to 105 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 7 mg/kg, sc measured after 15 to 105 mins
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Fraction unbound in plasma of human CGRPalpha-induced migraine marmoset model at 7 mg/kg, sc measured after 15 to 105 mins
Assay data:3 Tested
SummaryPubMed Citation
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 7 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 15 to 105 mins by laser doppler method relative to control
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 3 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 15 to 105 mins by laser doppler method relative to control
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 7 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 105 mins by laser doppler method relative to control
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 7 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 60 mins by laser doppler method relative to control
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 7 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 15 mins by laser doppler method relative to control
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 5 mg/kg, sc administered 30 mins after CGRPalpha stimulation measured after 15 mins by laser doppler method relative to control
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 5 mg/kg, sc administered 30 mins after CGRP stimulation and measured after 60 mins by laser doppler method relative to control
Antimigraine activity in human CGRPalpha-induced migraine marmoset model assessed as reduction in facial blood flow at 5 mg/kg, sc administered 30 mins after CGRP stimulation and measured after 105 mins by laser doppler method relative to control
Agonist activity at beta3 adrenergic receptor in marmoset urinary bladder smooth muscle strips assessed as induction of KCl-precontracted muscle relaxation treated every 20 mins
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Effect on absolute power in alpha band in common marmoset at 0.3 to 3 mg/kg, po by electroencephalography analysis
Antipsychotic-like activity in common marmoset assessed as induction of reduction in power in beta band at 1 mg/kg, po measured at 30 mins by electroencephalography analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Antipsychotic-like activity in common marmoset assessed as induction of increase in absolute power in delta band at 1 mg/kg, po measured at 30 mins by electroencephalography analysis
Antipsychotic-like activity in common marmoset assessed as induction of increase in theta band power at 3 mg/kg, po measured at 60 mins by electroencephalography analysis
Antipsychotic-like activity in common marmoset assessed as induction of increase in absolute power in delta band at 3 mg/kg, po measured between 30 and 120 mins by electroencephalography analysis
Sedative or hypnotic effect in marmoset assessed as number of animal jumps at 3 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 22.3 +/- 2.5 No_unit)
Sedative or hypnotic effect in marmoset assessed as number of animal jumps at 1 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 22.3 +/- 2.5 No_unit)
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