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Antagonist activity at Meleagris P2Y1R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization at 100 uM by FLIPR assay relative to control
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Meleagris gallopavo smooth muscle myosin 2 ATPase activity
Assay data:1 Tested
SummaryPubMed Citation
Agonist activity at turkey P2Y1R expressed in 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at turkey P2Y purinoceptor 1 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry
Assay data:9 Active, 4 Activity ≤ 1 µM, 12 Tested
Agonist activity at turkey P2Y purinoceptor 1 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration at 100 uM by spectrofluorimetry
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at turkey P2Y purinoceptor 1 expressed in human 1321N1 cells assessed as inhibition of 2-Sme-ADP-induced increase in intracellular calcium concentration by spectrofluorimetry
Assay data:8 Tested
Agonist activity at turkey P2Y1 receptor expressed in human 132N1 receptor assessed as induction of intracellular calcium mobilization
Assay data:7 Active, 4 Activity ≤ 1 µM, 8 Tested
Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 5 Tested
Antagonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as inhibition of 2-MeS-ADP-induced increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis
Assay data:3 Tested
Inhibition of myosin light chain kinase (MLCK) from turkey gizzard
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythrocyte ghosts
Assay data:13 Active, 8 Activity ≤ 1 µM, 14 Tested
Inhibition of [3H]dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes.
Assay data:13 Active, 13 Activity ≤ 1 µM, 20 Tested
Antagonism of PLC stimulation elicited by 10(nM) 2-Me SADP in turkey RBC
Assay data:9 Active, 5 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Tested in vitro for effective concentration required for stimulation of phospholipase C (PLC) against [3H]inositol labeled Turkey Erythrocyte P2Y purinoceptor 1
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythrocyte ghosts; small decrease
Assay data:3 Active, 3 Tested
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythrocyte ghosts; NE=not effective
Assay data:2 Tested
Assay data:16 Tested
Inhibition of [3H]dihydroalprenolol binding ([3H]-DHA) to beta-1-adrenoceptor from turkey erythrocyte membranes; Not active
Antagonism of PLC stimulation elicited by 30(nM) 2-Me SADP in turkey RBC
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