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Toxicity in duck assessed as inflammatory response in liver at 2.5 to 10 mg/kg, IG administered once daily for first 10 days followed by 10 to 40 mg/kg, IG for another 18 days by hematoxyin-eosin staining based light microscopic analysis
Assay data:1 Tested
SummaryPubMed Citation
Toxicity in duck assessed as liver hemorrhage at 2.5 to 10 mg/kg, IG administered once daily for first 10 days followed by 10 to 40 mg/kg, IG for another 18 days by hematoxyin-eosin staining based light microscopic analysis
Toxicity in duck assessed as liver necrosis at 2.5 to 10 mg/kg, IG administered once daily for first 10 days followed by 10 to 40 mg/kg, IG for another 18 days by hematoxyin-eosin staining based light microscopic analysis
Toxicity in duck assessed as body weight gain at 2.5 to 10 mg/kg, IG administered once daily for first 10 days followed by 10 to 40 mg/kg, IG for another 18 days
Toxicity in duck assessed as body weight loss at 2.5 to 10 mg/kg, IG administered once daily for first 10 days followed by 10 to 40 mg/kg, IG for another 18 days
Toxicity in duck assessed as animal survival at 2.5 to 10 mg/kg, IG administered once daily for first 10 days followed by 10 to 40 mg/kg, IG for another 18 days
Toxicity against Pekin duck infected with HBV assessed as change in body weight at 0.1 to 0.4 mmol/kg, po twice daily for 14 days administered via gavage and measured every day during compound dosing
Assay data:2 Tested
Toxicity against Pekin duck infected with HBV assessed as change in body weight at 0.2 to 0.4 mmol/kg, po once daily for 14 days and measured every day during compound dosing
Oral bioavailability in duck
Acute toxicity in Anas platyrhynchos (mallard duck) dosed with diet
Summary
Inhibition of duck liver FASN ketoreductase activity
Assay data:5 Tested
Inhibition of duck liver FASN
Assay data:8 Active, 1 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
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