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Inhibition of Mycobacterium tuberculosis H37Rv TMPK expressed in Escherichia coli by coupled enzyme based spectrophotometric analysis
Assay data:24 Active, 10 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Mycobacterium tuberculosis recombinant DprE1 expressed in Escherichia coli assessed as formation of resorufin using FPR as substrate by Amplex Red hydrogen/peroxidase coupled assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Activation of Mycobacterium tuberculosis NDH-2 overexpressed in mc24517 inverted membrane vesicles assessed as increase in NADH oxidation
Assay data:1 Tested
SummaryPubMed Citation
Disruption of membrane integrity Mycobacterium tuberculosis H37Rv assessed as disturbance in energy homeostasis by measuring reduction in ATP content at 0.125 to 2.5 ug/ml measured after 24 hrs by luciferase based bioluminescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Mycobacterium tuberculosis H37Rv FAAL28 Spectra expressed in Escherichia coli BL21(DE3) cells assessed as cleavage of MEsG by spectroscopic analysis
Assay data:22 Active, 5 Activity ≤ 1 µM, 47 Tested
Inhibition of Mycobacterium tuberculosis H37Rv FACL19 Spectra expressed in Escherichia coli BL21(DE3) cells assessed as cleavage of MEsG by spectroscopic analysis
Assay data:4 Active, 47 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Mycobacterium tuberculosis H37Rv FAAL32 expressed in Escherichia coli BL21(DE3) cells incubated for 2 hrs in presence of [C14] fatty acid by SDS-PAGE analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Mycobacterium tuberculosis H37Rv His-tagged FACL19 expressed in Escherichia coli
Inhibition of Mycobacterium tuberculosis H37Rv His-tagged FAAL28 expressed in Escherichia coli
Inhibition of Multidrug resistance efflux pump in Mycobacterium tuberculosis H37Rv assessed as reduction in rifampicin MIC at 1.56 ug/ml measured by ethidium bromide accumulation assay
Inhibition of Multidrug resistance efflux pump in Mycobacterium tuberculosis H37Rv assessed as relative final fluorescence at 6.26 ug/ml measured by ethidium bromide accumulation assay
Inhibition of Multidrug resistance efflux pump in Mycobacterium tuberculosis H37Rv assessed as measuring relative final fluorescence at 128 ug/ml measured by ethidium bromide accumulation assay
Substrate activity at Mycobacterium tuberculosis H37Rv BlaC expressed in Escherichia coli BL21 (DE3) assessed as compound hydrolysis by measuring Km by kinetic based analysis
Inhibition of Mycobacterium tuberculosis H37Rv DprE1 using FAD as substrate by resazurin based assay
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Non-covalent inhibition of DprE1 in Mycobacterium tuberculosis H37Rv measured after 7 days by microplate Alamar blue assay
Assay data:12 Tested
Inhibition of Mycobacterium tuberculosis H37Rv DprE1 assessed as increase in trehalose dimycolates accumulation at 100 x MIC incubated for 24 hrs using [14C]acetate by TLC based metabolic labelling assay
Assay data:2 Active, 2 Tested
Inhibition of Mycobacterium tuberculosis H37Rv DprE1 assessed as increase in trehalose monomycolates accumulation at 100 x MIC incubated for 24 hrs using [14C]acetate by TLC based metabolic labelling assay
Inhibition of Mycobacterium tuberculosis H37Rv ThyX expressed in Escherichia coli BL21(DE3) using 100 uM dUMP as substrate in absence of FAD cofactor at 200 uM incubated for 10 mins prior to the injection of NADPH and measured upto 20 mins by NADPH oxidase based spectrophotometric analysis
Inhibition of Mycobacterium tuberculosis H37Rv ThyX expressed in Escherichia coli BL21(DE3) using 10 uM dUMP as substrate in presence of FAD cofactor at 200 uM incubated for 10 mins prior to the injection of NADPH and measured upto 20 mins by NADPH oxidase based spectrophotometric analysis
Inhibition of Mycobacterium tuberculosis H37Rv ThyX expressed in Escherichia coli BL21(DE3) using 100 uM dUMP as substrate in presence of FAD cofactor at 200 uM incubated for 10 mins prior to the injection of NADPH and measured upto 20 mins by NADPH oxidase based spectrophotometric analysis relative to control
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