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Inhibition of Plasmodium vivax dihydrofolate reductase measured after 48 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiplasmodial activity against Plasmodium vivax Brazilian field isolates infected in human erythrocytes measured after 48 to 72 hrs by Giemsa staining based microscopic analysis
Inhibition of Plasmodium vivax HGPRT using PRib-PP as substrate by spectrophotometric assay
Assay data:14 Active, 12 Activity ≤ 1 µM, 15 Tested
Inhibition of recombinant Plasmodium vivax SUB1 using SERA4st1F-6R1 as substrate by fluorescence spectrophotometer
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Plasmodium vivax SUB1
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of recombinant C-terminal 6-His tagged Plasmodium vivax SUB1 expressed in baculovirus expression system
Antimalarial activity against Plasmodium vivax assessed as inhibition of sporogony in Anopheles sp. mosquito fed with blood containing plasma isolated from compound treated parasite-infected human observed after 7 days
Antimalarial activity against Plasmodium vivax assessed as reduction in oocyte infection in Anopheles darlingi mosquito fed with blood containing plasma isolated from compound treated human observed after 4 days relative to control
Antimalarial activity against Plasmodium vivax assessed as reduction in oocyte infection in Anopheles sp. mosquito fed with blood containing plasma isolated from compound treated human observed after 4 days relative to control
Antimalarial activity against Plasmodium vivax assessed as reduction in oocyte burden in Anopheles sp. mosquito midgut fed with blood isolated from compound treated parasite-infected human at 40 ng/ml observed after 7 days relative to control
Antimalarial activity against Plasmodium vivax assessed as reduction in infection in Anopheles sp. mosquito midgut fed with blood isolated from compound treated parasite-infected human at 40 ng/ml observed after 7 days relative to control
Antimalarial activity against Plasmodium vivax assessed as sporogony lethality in Anopheles darlingi mosquito fed with blood isolated from compound treated parasite-infected human observed after 7 days by measuring reduction in parasite prevalence level at Lc50 relative to control
Inhibition of Plasmodium vivax G6PD
Inhibition of Plasmodium vivax HGPRT using PRib-PP as substrate at 90 uM by spectrophotometric assay
Assay data:3 Tested
Binding affinity to Plasmodium falciparum PMX assessed as dissociation constant by SPR analysis
Inhibition of Plasmodium vivax PMX by FRET assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of Plasmodium vivax PI4K
Antimalarial activity against Plasmodium vivax
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Plasmodium vivax DHODH
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