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Antibacterial activity against Legionella pneumophila subsp. pneumophila
Assay data:18 Tested
SummaryPubMed Citation
Inhibition of Legionella pneumophila Mip assessed as reduction in PPIase activity using succinyl-Ala-Leu-Pro-Phe-4-nitroanilide as substrate incubated for 4 mins by absorbance method
Assay data:3 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of 5-(3-(4-(((5S,6S)-10-(3,5-dichlorophenylsulfonyl)-2-oxo-5-vinyl-3,10-diazabicyclo[4.3.1]decan-3-yl)methyl)-1H-1,2,3-triazol-1-yl)propylcarbamoyl)-2-(6-(dimethylamino)-3-(dimethyliminio)-3,10-dihydroanthracen-9-yl)benzoate from Legionella pneumophila Mip after 30 mins by fluorescence polarization assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antibacterial activity against Legionella pneumophila Corby infected in differentiated human THP1 cells assessed as bacterial growth inhibition after 24 hrs
Assay data:2 Tested
Inhibition of Mip PPIase activity in Legionella pneumophila
Assay data:14 Active, 27 Tested
Inhibition of Legionella pneumophila NTPDase
Assay data:1 Tested
Binding affinity to Legionella pneumophila 15N-labeled Mip (77 to 213 residues) assessed as chemical shift changes of amide resonance by NMR-HSQC method
Assay data:2 Active, 2 Tested
Anti-infective activity against Legionella pneumophila harboring GFP in Acanthamoeba castellanii assessed as inhibition of bacterial replication at 30 uM by spectrophotometric method relative to vehicle control
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antibacterial activity against Legionella pneumophila axenic forms harboring GFP at 30 uM by spectrophotometric method
Assay data:9 Active, 13 Tested
Binding affinity to Legionella pneumophila recombinant PAH by DSF assay
Assay data:1 Active, 1 Tested
Mixed inhibition of Legionella pneumophila recombinant PAH for enzyme-substrate complex by DSF assay method using L-Phe as substrate
Mixed inhibition of Legionella pneumophila recombinant PAH for free enzyme by DSF assay using L-Phe as substrate
Uncompetitive inhibition of Legionella pneumophila recombinant PAH for enzyme-substrate complex by DSF assay using L-Phe as substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Uncompetitive inhibition of Legionella pneumophila recombinant PAH for free enzyme by DSF assay using L-Phe as substrate
Non-competitive inhibition of Legionella pneumophila recombinant PAH for enzyme-substrate complex by DSF assay using BH4 as cofactor
Non-competitive inhibition of Legionella pneumophila recombinant PAH for free enzyme by DSF assay using BH4 as cofactor
Inhibition of Legionella pneumophila recombinant PAH assessed as tyrosine production by DSF assay using 1 mM L-Phe as substrate and 200 uM BH4 as cofactor
Assay data:7 Active, 19 Tested
Inhibition of PAH in Legionella pneumophila 130b lysate assessed as residual activity at 10 uM by direct detect spectrometer
Antibacterial activity against Legionella pneumophila 130b expressing phhA mutant assessed as bacterial growth at 20 uM after 24 hrs by spectrometer
Antibacterial activity against Legionella pneumophila 130b assessed as bacterial growth at 20 uM after 24 hrs by spectrometer
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