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Toxicity in Mastomys coucha infected with third stage infective larvae (L3) form of Brugia malayi assessed as normal behaviour at at 100 mg/kg, sc administered for 5 days measured on day 91 post-initiation of drug treatment
Assay data:2 Tested
SummaryPubMed Citation
Toxicity against Mastomys coucha assessed as mortality at 50 to 100 mg/kg, ip for 5 days measured after 15 days
Assay data:3 Tested
Toxicity against Mastomys coucha assessed as methemoglobin levels at 15 mg/kg after 3 days
Assay data:13 Tested
Tested for in vivo antifilarial activity against Litomosoides carinii microfilariae infection in Mastomys coucha at 6 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load
Assay data:1 Tested
Summary
Tested for in vivo antifilarial activity against Litomosoides carinii microfilariae infection in Mastomys coucha at 350 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load
Tested for in vivo antifilarial activity against Litomosoides carinii microfilariae infection in Mastomys coucha at 30 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load with 30% sterilization of female worms
Tested for in vivo antifilarial activity against Litomosoides carinii macrofilariae infection in Mastomys coucha at 6 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load
Tested for in vivo antifilarial activity against Litomosoides carinii macrofilariae infection in Mastomys coucha at 350 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load
Tested for in vivo antifilarial activity against Litomosoides carinii macrofilariae infection in Mastomys coucha at 30 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load with 30% sterilization of female worms
Tested for in vivo antifilarial activity against A. viteae microfilariae infection in Mastomys coucha at 50 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load
Tested for in vivo antifilarial activity against Acanthocheilonema viteae microfilariae infection in Mastomys coucha at 50 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load
Assay data:4 Tested
Tested for in vivo antifilarial activity against Acanthocheilonema viteae macrofilariae infection in Mastomys coucha at 50 mg/kgx 5 days after ip administration, expressed as % reduction in parasite load
Assay data:5 Tested
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