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Inhibition of Burkholderia pseudomallei gamma carbonic anhydrase preincubated with enzyme for 15 mins by phenol red-based stopped-flow CO2 hydration assay
Assay data:18 Active, 18 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of Burkholderia pseudomallei beta carbonic anhydrase preincubated with enzyme for 15 mins by phenol red-based stopped-flow CO2 hydration assay
Assay data:19 Active, 14 Activity ≤ 1 µM, 19 Tested
Binding affinity to Burkholderia pseudomallei IspF at pH 8 measured by isothermal titration calorimetry method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Burkholderia pseudomallei IspF at pH 6 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF at pH 7.4 measured by isothermal titration calorimetry method
Assay data:4 Tested
Potency index, ratio of Acetazolamide Ki to test compound Ki for Burkholderia pseudomallei gamma carbonic anhydrase preincubated with enzyme for 15 mins by phenol red-based stopped-flow CO2 hydration assay
SummaryPubMed Citation
Binding affinity to Burkholderia pseudomallei IspF by STD NMR analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Ratio of apparent Kd for Burkholderia pseudomallei IspF at pH 6 to apparent Kd for Burkholderia pseudomallei IspF at pH 7.4
Binding affinity to Burkholderia pseudomallei IspF assessed as change in entropy at pH 8 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF assessed as change in entropy at pH 6 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF assessed as change in entropy at pH 7.4 measured by isothermal titration calorimetry method
Assay data:2 Tested
Binding affinity to Burkholderia pseudomallei IspF assessed as change in enthalpy at pH 8 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF assessed as change in enthalpy at pH 6 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF assessed as change in enthalpy at pH 7.4 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF assessed as change in free energy at pH 8 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF assessed as change in free energy at pH 6 measured by isothermal titration calorimetry method
Binding affinity to Burkholderia pseudomallei IspF assessed as change in free energy at pH 7.4 measured by isothermal titration calorimetry method
Inhibition of Burkholderia pseudomallei IspF assessed as inhibition of CMP production using CDP-ME2P as substrate at 120 uM measured by HPLC method
Antibacterial activity against Burkholderia pseudomallei after 18 to 24 hrs by Alamar blue dye-based colorimetric assay
Assay data:13 Tested
Binding affinity to Burkholderia pseudomallei IspF by surface plasmon resonance analysis
Assay data:1 Active, 1 Tested
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