PubChem BioAssay Links for Taxonomy (Select 263) - PubChem BioAssay - NCBI

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Select item 19281571.

Inhibition of Francisella tularensis FabI by addition of crotonyl-CoA as substrate preincubated for 10 mins followed by substrate addition in presence of NAD by spectrophotometer

Source:: ChEMBL

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1928157

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19484492.

Antibacterial activity against Francisella tularensis-Schu S4 assessed as inhibition of bacterial growth

Source:: ChEMBL

Assay data:3 Tested

AID:: 1948449

Summary PubMed Citation

Select item 17185703.

Inhibition of Francisella tularensis FabZ

Source:: ChEMBL

Assay data:1 Tested

AID:: 1718570

Summary PubMed Citation

Select item 16256004.

Antibacterial activity against Francisella tularensis LVS after 18 to 24 hrs by Alamar blue dye-based colorimetric assay

Source:: ChEMBL

Assay data:26 Tested

AID:: 1625600

Summary PubMed Citation

Select item 15573485.

Inhibition of Francisella tularensis IMPDH expressed in Escherichia coli BL21(DE3) deletion in guaB gene using IMP as substrate preincubated for 10 mins followed by substrate addition in presence of NAD by spectrophotometer

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1557348

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 14619386.

Inhibition of recombinant His6-tagged Francisella tularensis beta-CA (227 residues) expressed in Escherichia coli BL21(DE3) incubated for 15 mins by stopped-flow CO2 hydration assay

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 38 Tested

AID:: 1461938

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 14534107.

Inhibition of Francisella tularensis beta-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay

Source:: ChEMBL

Assay data:19 Active, 2 Activity ≤ 1 µM, 39 Tested

AID:: 1453410

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 13927518.

Inhibition of Francisella tularensis FabI

Source:: ChEMBL

Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested

AID:: 1392751

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 13911689.

Antibacterial activity against Francisella tularensis Utah 112 after 20 hrs by broth microdilution assay

Source:: ChEMBL

Assay data:1 Activity ≤ 1 µM, 9 Tested

AID:: 1391168

Summary Compounds, activity ≤ 1 µM PubMed Citation

Select item 137731210.

Inhibition of Francisella tularensis FabI enoyl reductase assessed as dissociation half life preincubated for 5 hrs in presence of NADH followed by crotonyl-CoA substrate addition by spectrophotometric method

Source:: ChEMBL

Assay data:1 Tested

AID:: 1377312

Summary PubMed Citation

Select item 127220011.

Prodrug activation assessed as Francisella tularensis PNP-mediated compound cleavage at 100 uM by reverse phase HPLC analysis

Source:: ChEMBL

Assay data:6 Tested

AID:: 1272200

Summary PubMed Citation

Select item 122672412.

Antimicrobial activity against Francisella tularensis incubated for 16 to 18 hrs by macrodilution method

Source:: ChEMBL

Assay data:2 Active, 3 Tested

AID:: 1226724

Summary Compounds, Active PubMed Citation

Select item 119340213.

Antimicrobial activity against Francisella tularensis BEI/ATCC UTAH 112 measured after overnight incubation

Source:: ChEMBL

Assay data:16 Tested

AID:: 1193402

Summary PubMed Citation

Select item 119191214.

Antimicrobial activity against Francisella tularensis Utah 112 measured after overnight incubation by microdilution method

Source:: ChEMBL

Assay data:10 Tested

AID:: 1191912

Summary PubMed Citation

Select item 112003915.

Antibacterial activity against Francisella tularensis harboring SPase with aspargine residue at position 29 by modified CLSI microbroth dilution method

Source:: ChEMBL

Assay data:1 Tested

AID:: 1120039

Select item 73305316.

Inhibition of Francisella tularensis DNA gyrase subunit B using ATP as substrate assessed as release of inorganic phosphate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis

Source:: ChEMBL

Assay data:33 Active, 19 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 33 Tested

AID:: 733053

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 73263417.

Inhibition of Francisella tularensis DNA topoisomerase 4 subunit B using ATP as substrate assessed as release of inorganic phosphate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis

Source:: ChEMBL

Assay data:31 Active, 7 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 32 Tested

AID:: 732634

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 73258018.

Inhibition of Francisella tularensis GyrB assessed as release of inorganic phosphate from ATP hydrolysis after 30 mins by coupled spectrophotometric assay

Source:: ChEMBL

Assay data:27 Active, 18 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested

AID:: 732580

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 73257919.

Inhibition of Francisella tularensis parE assessed as release of inorganic phosphate from ATP hydrolysis after 30 mins by coupled spectrophotometric assay

Source:: ChEMBL

Assay data:9 Active, 2 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 10 Tested

AID:: 732579

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 74979420.

Antibacterial activity against Francisella tularensis LVS at 0.2 ug/ml by Microplate Alamar Blue assay

Source:: ChEMBL

Assay data:7 Tested

AID:: 749794

Summary PubMed Citation

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BioActivity

Active Compounds (15)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (4)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (12)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (15)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (37)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (1)
BioAssays reporting BioActivity of RNAi reagents

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Literature Extraction (37)
BioAssays extracted from the literature

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PubChem BioAssay Links for Taxonomy (Select 263) (38)
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