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Cytotoxicity against CHO cells assessed as inhibition of cell growth
Assay data:1 Tested
SummaryPubMed Citation
Cytotoxicity against CHL cells assessed as inhibition of cell growth
Cytotoxicity against CHO-K1 cells
Cytotoxicity against CHO cells assessed as reduction in cell viability
Displacement of [125I]MCH from MCHR1 expressed in CHO cell membranes assessed as inhibition constant
Assay data:21 Active, 12 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cytotoxicity against CHO cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Induction of HMGCR degradation in CHO-7 cells incubated for 16 hrs by immunoblotting assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Cytotoxicity against CHO cells measured after 48 hrs by MTT assay
Assay data:10 Active, 1 Activity ≤ 1 µM, 16 Tested
Antiproliferative activity against CHO cells assessed as reduction in cell proliferation by MTT assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Anti-keratosis activity in vitamin-A-deficient hamster trachea in presence of beta-lactamase
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Cytotoxicity against Chinese hamster CHO cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 6 Tested
Cytotoxicity against Chinese hamster CHO cells assessed as reduction in cell viability by MTT assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 11 Tested
Assay data:2 Tested
Cytotoxicity against CHO cells assessed as cell growth inhibition incubated for 48 hrs by AlamarBlue assay
Assay data:1 Active, 1 Tested
Genotoxicity in CHO-K1 cells upto 100 uM incubated for 24 hrs in absence of rat liver S9 fraction by micronucleus test
Genotoxicity in CHO-K1 cells up to 50 uM incubated for 24 hrs in presence of rat liver S9 fraction by micronucleus test
Induction of degradation of endogenous HMGCR in CHO-7 cells assessed as decrease in protein level incubated for 16 hrs in sterol-depleted medium by immunoblot analysis
Induction of degradation of hamster HMGCR (TM1-8)-GFP (1 to 346 residues) transfected in CHO-7 cells incubated for 16 hrs in sterol-depleted medium by fluorescence based microplate reader assay
Assay data:39 Active, 21 Activity ≤ 1 µM, 43 Tested
Toxicity in CHO cells assessed as chromosomal aberration
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