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Human M1 receptor (Acetylcholine receptors (muscarinic))
Assay data:96 Active, 96 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Discovery of Novel Antagonists of Muscarinic Receptor M5: Counterscreen against human M1
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of Novel Negative Allosteric Modulators of Muscarinic Receptor M5: Counterscreen against human M1
Assay data:5 Tested
Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1
Assay data:5 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Development of the first CNS penetrant Muscarinic 5 (M5) Positive Allosteric Modulator based on a novel non-isatin core
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Development of a novel orthosteric Muscarinic 5 (M5) antagonist possessing a hig degree of muscarinic subtype selectivity
Discovery and characterization of a small molecule allosteric agonists of mas-related G-Protein coupled receptor X1 ( MrgX1)
Development of the First Potent, Selective and CNS penetrant M5 Negative Allosteric Modulator (NAM)
Development of inhibitors for mGluR7 (Eurofin Panel Assay Results)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Development of inhibitors for Menin-MLL Receptor(Eurofin Panel Assay Results)
Development of inhibitors for mGluR7/8 (Eurofin Panel Assay Results)
SummaryRelated BioAssays by Target
Development of inhibitors for PLD2 (Eurofin Panel Assay Results)
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Development of inhibitors for Dopamine D4 Receptors: Eurofin Panel Assay Results
Discovery of Selective Novel Positive Allosteric Modulators (PAM) of the Muscarinic Receptor (M5) in CHO cells expressing human M1 receptor
ML353 Eurofin Panel Assay for mGlu5 SAM Inhibitor (Probe Compound)
ML354 Eurofin Panel Assay for PAR4 Antagonists Inhibitor (Probe Compound)
ML352 Eurofin Panel Assay for Choline Transporter Inhibitor (Probe Compound)
ML347 Eurofin Panel Assay for BMP Inhibitor (Probe Compound)
Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity (hM1 CounterScreen)
Assay data:1 Active, 1 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Late-stage results from the probe development effort to identify antagonists of OPRK1: CEREP radiometric-based biochemical counterscreen panel assay
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