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Human TLR8 (Toll-like receptor family)
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase by HEK-blue reporter gene assay
Assay data:15 Active, 2 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human TLR3 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay
Assay data:22 Tested
SummaryPubMed CitationRelated BioAssays by Target
Up-regulation of CCL gene in human PBMC cells after 2 hrs
Assay data:2 Tested
SummaryPubMed Citation
Agonist activity at human TLR4 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay
Agonist activity at human TLR5 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay
Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay
Agonist activity at human TLR9 expressed in HEK293 cells assessed as induction of NF-kappaB activity by measuring extracellular secreted alkaline phosphatase up to 250 uM by HEK-blue reporter gene assay
Induction of proinflammatory cytokine release in human PBMC after 12 hrs
Assay data:5 Tested
Up-regulation of CXCL gene in human PBMC cells after 2 hrs
Adjuvantic activity in New Zealand White rabbit immunized with bovine alpha-lactalbumin on day 1, 15, and 28 assessed as anti-alpha-lactalbumin IgG level in serum at 100 ug measured on day 38 by ELISA
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Induction of transcriptional signature of inflammatory gene expression in human PBMC cells after 2 hrs
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