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NCATS Human Liver Microsomal (HLM) Stability Profiling
Assay data:542 Active, 900 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Increase the activity of the Burkholderia fixLJ 2-component system
Assay data:87 Active, 28704 Tested
SummaryCompounds, ActivePubMed Citation
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
SummaryCompounds, Active
UDP-glucuronosyltransferase Activity Assay from Article 10.3109/14756366.2010.518965: "The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors."
Assay data:2 Active, 20 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Fluorophore Displacement Assay from Article 10.1021/cb5005178: "Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein."
Assay data:5 Active, 2 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
hCA IX Enzyme Inhibition Assay from Article 10.1021/jm030912m: "Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition."
Assay data:2 Active, 2 Activity ≤ 1 µM, 5 Tested
Carbonic Anhydrase Enzyme Inhibition Assay from Article 10.1021/jm030912m: "Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition."
Antiallodynic activity in Swiss Webster mouse assessed as reversal of carrageenan-induced tactile allodynia at 30 ug/paw local peripheral administration pretreated with carrageenan for 6 days followed by compound addition and measured 6 hrs post compound treatment
Assay data:1 Active, 2 Tested
Antiinflammatory activity in Swiss Webster mouse assessed as reversal of carrageenan-induced paw edema at 30 ug/paw local peripheral administration pretreated with carrageenan for 6 days followed by compound addition and measured 6 hrs post compound treatment
Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mitochondria
Assay data:128 Active, 5056 Tested
Agonist activity at human TRPA1 Cys261Ala mutant expressed in HEK293 cells assessed as Ca2+ influx at 30 uM by fluorescence assay
Assay data:4 Active, 9 Tested
Cell-based high throughput primary assay to identify activators of GPR151
Assay data:6756 Active, 646675 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
MELAS cybrid survival enhancement under low glucose conditions
Assay data:264 Active, 4937 Tested
Anti-inflammatory activity in Swiss mouse assessed as inhibition of LPS-induced nitric oxide production in pleural washes at 100 mg/kg, ip pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Lowry/Griess analysis
Assay data:1 Tested
SummaryPubMed Citation
Anti-inflammatory activity in Swiss mouse assessed as inhibition of LPS-induced protein extravasation in thoracic cavity at 100 mg/kg, ip pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs
Anti-inflammatory activity in Swiss mouse assessed as inhibition of LPS-induced nitric oxide production in pleural washes at 100 ng/kg, ip pretreated for 1 hr followed by LPS stimulation measured after 24 hrs by Lowry/Griess analysis
Anti-inflammatory activity in Swiss mouse assessed as inhibition of LPS-induced pleural accumulation in eosiniphils at 100 mg/kg, ip pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by May-Grunwald-Giemsa staining-based Neubauer chamber based optical microscopy
Anti-inflammatory activity in Swiss mouse assessed as inhibition of LPS-induced pleural accumulation in neutrophils cells at 100 mg/kg, ip pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by May-Grunwald-Giemsa staining-based Neubauer chamber based optical microscopy
Lung cancer cell sensitization to miR-34 therapy: cell viability screen of compounds
Assay data:58 Active, 9908 Tested
Analgesic activity in Swiss albino mouse assessed as reduction in formalin-induced paw flinches in neurogenic phase at 5 mg/kg, ip dosed 30 mins before formalin injection measured up to 5 mins
Assay data:2 Tested
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