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In Vitro Assay from US Patent US9926281: "5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis"
Assay data:50 Active, 12 Activity ≤ 1 µM, 189 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:5 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:107 Active, 41 Activity ≤ 1 µM, 407 Tested
Inhibition of TRKB (unknown origin) at 10 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RAF-1/MEK1 kinase (unknown origin) at 10 uM
Inhibition of PKCalpha (unknown origin) at 10 uM
Inhibition of PKA (unknown origin) at 10 uM
SummaryPubMed Citation
Inhibition of p38alpha kinase (unknown origin) at 10 uM
Inhibition of MEK1/MAP2K1 (unknown origin) at 10 uM
Inhibition of Lyn A kinase (unknown origin) at 10 uM
Inhibition of FGFR1 kinase (unknown origin) at 10 uM
Inhibition of EGFR kinase (unknown origin) at 10 uM
Inhibition of CDC2/CDK1 (unknown origin) at 10 uM
Inhibition of CaMK2alpha (unknown origin) at 10 uM
Inhibition of Akt1/PKBalpha (unknown origin) at 10 uM
Inhibition of Abl kinase (unknown origin) at 10 uM
Inhibition of human ERG expressed in HEK293 cells measured at holding potential -80 mV at 10 uM by whole cell patch clam method
Assay data:4 Tested
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