BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 19411471.

Inhibition of maize HD1-A

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1941147

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19411462.

Inhibition of maize HD1-B

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1941146

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19191473.

Enzymatic Assay from US Patent US11535598: "Histone deacetylases (HDACs) inhibitors"

Source:: BindingDB

Protein Targets:: Histone deacetylase 1; ...
Total:: 4

Assay data:26 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 26 Tested

AID:: 1919147

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18023984.

Enzymatic HDAC Activity Assay from Article 10.1074/jbc.M113.490706: "Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability."

Source:: BindingDB

Protein Targets:: Histone deacetylase 1; ...
Total:: 10

Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1802398

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 16229725.

Inhibition of HDAC1 (unknown origin)

Source:: ChEMBL

Protein Target:: Histone deacetylase 1

Assay data:13 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 13 Tested

AID:: 1622972

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15784856.

Inhibition of recombinant full length human HDAC1 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 1

Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1578485

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14798157.

Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged recombinant human NCOR2 (395 to 489 residues) expressed in baculovirus-infected insect cells using RHKK(Ac)AMC as substrate after 60 mins by fluorimeter

Source:: ChEMBL

Protein Targets:: Histone deacetylase 3; ...
Total:: 2

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1479815

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14798148.

Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus-infected Sf21 insect cells using RHKK(Ac)AMC as substrate after 60 mins by fluorimeter

Source:: ChEMBL

Protein Target:: Histone deacetylase 1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1479814

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14798129.

Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus-infected Sf9 insect cells using RHKK(Ac)AMC as substrate after 90 mins by fluorimeter

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:22 Active, 13 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 24 Tested

AID:: 1479812

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 129928810.

Inhibition of recombinant human HDAC3/NCOR1 complex expressed in insect cells assessed as residual enzyme activity preincubated for 1 hr followed by addition of fluorogenic Ac-LGK-ac-AMC as substrate for 30 mins by fluorescence analysis

Source:: ChEMBL

Protein Targets:: Histone deacetylase 3; ...
Total:: 2

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1299288

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 123645011.

Inhibition of human HDAC6

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:11 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested

AID:: 1236450

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 123644412.

Inhibition of human HDAC3

Source:: ChEMBL

Protein Target:: Histone deacetylase 3

Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested

AID:: 1236444

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 123644313.

Inhibition of human HDAC2

Source:: ChEMBL

Protein Target:: Histone deacetylase 2

Assay data:10 Active, 5 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 10 Tested

AID:: 1236443

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 123644214.

Inhibition of human HDAC1

Source:: ChEMBL

Protein Target:: Histone deacetylase 1

Assay data:11 Active, 5 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 11 Tested

AID:: 1236442

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 112732715.

Inhibition of human HDAC6 using fluorogenic tetrapeptide RHKKAc as substrate

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:7 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 8 Tested

AID:: 1127327

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 76993116.

Inhibition of human recombinant HDAC6 expressed in baculovirus/sf9 cells using RHKKAc as substrate

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:22 Active, 1 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 22 Tested

AID:: 769931

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 76039017.

Inhibition of human recombinant HDAC1 by Michaelis-Menten equation analysis

Source:: ChEMBL

Protein Target:: Histone deacetylase 1

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 14 Tested

AID:: 760390

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 54165218.

Inhibition of human HDAC6 by fluorimetric assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:13 Active, 2 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested

AID:: 541652

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 52499919.

Inhibition of HDAC6 by in vitro deacetylation assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested

AID:: 524999

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 49680620.

Inhibition of human HDAC6

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:16 Active, 2 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested

AID:: 496806

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (4)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (47)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (47)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (47)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (47)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (46)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program

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