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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
Summary
Inhibition of recombinant human N-terminal His6-tagged TRAP1 (60 to 704 residues) ATPase activity expressed in Escherichia coli BL21-CodonPlus-RIL after overnight incubation by BioMol green dye-based assay
Assay data:7 Active, 4 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: Secondary screen by immunofluorescence
Assay data:150 Active, 107 Activity ≤ 1 µM, 216 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytotoxicity against human A2058 cells in presence of HSF1 knock down treatment
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cytotoxicity against human A375 cells in presence of HSF1 knock down treatment
Cytotoxicity against human A2058 cells in absence of HSF1 knock down treatment
Cytotoxicity against human A375 cells in absence of HSF1 knock down treatment
Inhibition of full-length HSP90 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Cytotoxicity against human GTL16 cells after 72 hrs by CellTitre-Glo assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 12 Tested
Inhibition of HSP90 (unknown origin) assessed as down regulation of Hsp70 after 20 hrs by cell-based assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
Inhibition of HSP90 (unknown origin) assessed as down regulation of c-Met after 20 hrs by cell-based assay
Inhibition of N-terminal His-tagged HSP90-alpha (unknown origin) after 2 hrs by spectrophotometry
Assay data:13 Active, 12 Activity ≤ 1 µM, 14 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
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