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Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY5_PLB cell viability assay
Assay data:980 Active, 10 Activity ≤ 1 nM, 428 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1S_ATCC cell viability assay
Assay data:1053 Active, 13 Activity ≤ 1 nM, 437 Activity ≤ 1 µM, 1911 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS21BM_JCRB cell viability assay
Assay data:650 Active, 358 Activity ≤ 1 nM, 751 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: JIM1_ECACC cell viability assay
Assay data:457 Active, 27 Activity ≤ 1 nM, 619 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KHM11_PLB cell viability assay
Assay data:572 Active, 29 Activity ≤ 1 nM, 524 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: Karpas417_ECACC cell viability assay
Assay data:508 Active, 171 Activity ≤ 1 nM, 712 Activity ≤ 1 µM, 1912 Tested
Cmax in C57BL/6 mouse at 2 mg/kg, sc by LC-MS analysis
Assay data:10 Active, 8 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antagonist activity at human V2 receptor expressed in CHO cells assessed as reduction in vasopressin induced cAMP production preincubated for 30 mins followed by vasopressin stimulation and measured after 30 mins
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of conivaptan-red from SNAP-tagged V2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition constant measured after 2 hrs by HTRF assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Displacement of [3H]-vasopressin from human V1A receptor expressed in CHO cells membrane by microbeta scintillation counter analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of conivaptan-red from SNAP-tagged human V2 receptor expressed in HEK293 cells measured after 1 hr by HTRF assay
Assay data:22 Active, 21 Activity ≤ 1 µM, 22 Tested
Displacement of [3H]-arginine-vasopressin from human V2 receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 7 Tested
Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate reader
Assay data:10 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand binding assay
Assay data:16 Active, 6 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
Radioligand Binding Assay to HeLa Cells from Article 10.1016/s0968-0896(99)00101-7: "7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): a potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist."
Assay data:16 Active, 16 Activity ≤ 1 µM, 16 Tested
Antagonist activity at human AVPR2 by PathHunter beta-arrestin assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Drug concentration at steady state in human at 15 to 60 mg, po QD after 24 hrs
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds
Assay data:1106 Active, 14 Activity ≤ 1 nM, 6478 Activity ≤ 1 µM, 7578 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
qHTS assay to identify small molecule agonists of the AP-1 signaling pathway
Assay data:49 Active, 4 Activity ≤ 1 nM, 99 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation
Assay data:74 Activity ≤ 1 nM, 704 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
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