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Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:96 Active, 35 Activity ≤ 1 µM, 927 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:19 Active, 11 Activity ≤ 1 µM, 692 Tested
Cytotoxicity against mouse BaF3 cells expressing EGFR L858R/C797S mutant assessed as reduction in cell viability incubated for 96 hrs by CellTiter-Glo assay
Assay data:15 Active, 10 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 10 mins by HTRF assay
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of EGFR L858R/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 20 mins by HTRF assay
Assay data:15 Active, 7 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Inhibition of wild type EGFR (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 25 mins by HTRF assay
Assay data:15 Active, 11 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Inhibition of full length mouse GST-tagged BRAF V600E mutant preincubated for 60 mins followed by addition of N-terminal His-tagged full length human MEK1 incubated for 25 mins in presence of ATP by ELISA assay
Assay data:11 Active, 3 Activity ≤ 1 µM, 11 Tested
Inhibition of recombinant 6His-tagged EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) autophosphorylation expressed in baculovirus infected Sf9 insect cells preincubated for 10 mins followed by ATP and MgCl2 addition measured after 60 mins by DELFIA/time-resolved fluorometric analysis
Assay data:11 Active, 4 Activity ≤ 1 µM, 11 Tested
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by propidium iodide staining based fluorometer assay
Assay data:55 Active, 7 Activity ≤ 1 µM, 70 Tested
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 48 hrs by propidium iodide staining based fluorometer assay
Assay data:54 Active, 7 Activity ≤ 1 µM, 70 Tested
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 48 hrs by propidium iodide staining based fluorometer assay
Assay data:56 Active, 7 Activity ≤ 1 µM, 70 Tested
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by propidium iodide staining based fluorometer assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by propidium iodide staining based fluorometer assay
Assay data:54 Active, 8 Activity ≤ 1 µM, 70 Tested
Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for 48 hrs by propidium iodide staining based fluorometer assay
Assay data:57 Active, 7 Activity ≤ 1 µM, 70 Tested
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by propidium iodide staining based fluorometer assay
Assay data:56 Active, 8 Activity ≤ 1 µM, 70 Tested
Antiproliferative activity against human HT-29 cells by MTT assay
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Antiproliferative activity against human PANC-1 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
Inhibition of EGFR (unknown origin)
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
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