BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 20

Select item 18061771.

JAK Caliper Enzyme Assay from US Patent US11197867: "Aminopyrimidinyl compounds"

Source:: BindingDB

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 4

Assay data:113 Active, 112 Activity ≤ 1 µM, 113 Tested

AID:: 1806177

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18054562.

JAK Caliper Enzyme Assay at 1 mM ATP from US Patent US10980815: "Aminopyrimidinyl compounds"

Source:: BindingDB

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 4

Assay data:113 Active, 112 Activity ≤ 1 µM, 113 Tested

AID:: 1805456

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18039473.

Caliper Enzyme Assay from US Patent US10463675: "Aminopyrimidinyl compounds"

Source:: BindingDB

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 4

Assay data:113 Active, 112 Activity ≤ 1 µM, 113 Tested

AID:: 1803947

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17968204.

Caliper Enzyme Assay from US Patent US9663526: "Aminopyrimidinyl compounds"

Source:: BindingDB

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 1

Assay data:113 Active, 112 Activity ≤ 1 µM, 113 Tested

AID:: 1796820

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 16598065.

Inhibition of JAK1/TYK2 in human whole blood assessed as cytokine inhibition profile by flow cytometric analysis relative to control

Source:: ChEMBL

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 2

Assay data:10 Active, 10 Activity ≤ 1 µM, 11 Tested

AID:: 1659806

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16598056.

Inhibition of JAK1/TYK2 in human whole blood assessed as free fraction of IFNalpha-induced STAT phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 2

Assay data:10 Active, 10 Activity ≤ 1 µM, 11 Tested

AID:: 1659805

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16598047.

Inhibition of JAK1/JAK2 in human whole blood assessed as free fraction of of IL27-induced STAT3 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659804

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16597858.

Inhibition of human recombinant VEGFR2 in presence of substrate Ulight-CAGAGAIETDKEYYTVKD and Km ATP

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659785

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16597779.

Inhibition of TYK2/JAK2 in human whole blood assessed as free fraction of of IL23-induced STAT3 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659777

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165977610.

Inhibition of TYK2/JAK2 in human whole blood assessed as free fraction of of IL12-induced STAT4 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659776

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165977511.

Inhibition of JAK1/TYK2 in human whole blood assessed as free fraction of IL10-induced STAT3 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659775

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165977412.

Inhibition of JAK1/JAK3 in human whole blood assessed as free fraction of IL21-induced STAT3 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659774

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165977313.

Inhibition of JAK1/JAK3 in human whole blood assessed as free fraction of IL15-induced STAT5 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659773

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165977214.

Inhibition of JAK1/JAK2 in human whole blood assessed as free fraction of IFNgamma-induced STAT phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659772

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165977115.

Inhibition of JAK1/JAK2 in human whole blood assessed as free fraction of IL6-induced STAT1 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659771

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165977016.

Inhibition of JAK1/TYK2 in human whole blood assessed as free fraction of IFNalpha-induced STAT3 phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1659770

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165976717.

Inhibition of JAK1/TYK2 in human whole blood assessed as reduction in IFNalpha-induced STAT phosphorylation by flow cytometry

Source:: ChEMBL

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 2

Assay data:10 Active, 7 Activity ≤ 1 µM, 11 Tested

AID:: 1659767

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165976518.

Inhibition of human recombinant TYK2 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQID and ATP by mobility shift assay

Source:: ChEMBL

Protein Target:: Non-receptor tyrosine-protein kinase TYK2

Assay data:14 Active, 13 Activity ≤ 1 µM, 14 Tested

AID:: 1659765

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165976419.

Inhibition of human recombinant JAK1 assessed as level of phosphorylation in presence of peptide substrate 5FAM-KKSRGDYMTMQUID and ATP by mobility shift assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK1

Assay data:13 Active, 12 Activity ≤ 1 µM, 14 Tested

AID:: 1659764

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 165976320.

Inhibition of human recombinant JAK2 assessed as level of phosphorylation in presence of peptide substrate FITC-KGGEEEEYFELVKK and ATP by mobility shift assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK2

Assay data:13 Active, 7 Activity ≤ 1 µM, 14 Tested

AID:: 1659763

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (20)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (20)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (20)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (20)
BioAssays extracted from the literature

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BioAssays, activity concentration at/below 1 uM for PubChem Compound (Select 118878262)
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